DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and si:ch211-132b12.2

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001038688.1	Gene:	si:ch211-132b12.2 / 571877	ZFINID:	ZDB-GENE-050420-178	Length:	582	Species:	Danio rerio

Alignment Length:	547	Identity:	233/547 - (42%)
Similarity:	350/547 - (63%)	Gaps:	15/547 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFH 138
            |..||.|.||:|||.|..:.|||||||||:||:||||||||||.:|::..|:|||.:|.|:||:.
Zfish    11 RGNWGSKTEFILAVAGIVIGLGNVWRFPYLCYKNGGGAFLVPYLVFVVTCGVPLFLLETAMGQYT 75

  Fly   139 RCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTEN 203
            :.|.::.|.|:||..:|:|||..||.:|..|||..|:.||::||..||:|:|||.||||.|||:.
Zfish    76 QEGGITCWHRLCPLAEGIGYAGQLIVLYSCMYYIIILAWALFYLAFSFSSQLPWASCDNIWNTDA 140

  Fly   204 CMQVTSENFTEL-------ATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFS 261
            |:.: :||...|       :||...||::.:||.  ...|::.:|.:...:.||:..::::.||.
Zfish   141 CVNL-AENKLNLSTPMLLNSTSSVTEFWQHRVLA--LSGGIEKVGKINWEILLCLIVMWIICYFC 202

  Fly   262 LWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIF 326
            :||||:|.||||:.||..|||:|::||:||::||||.:|:.:||.||..:|.:.:||::|.:|||
Zfish   203 VWKGVKSTGKVVYFTATFPYVMLLVLLIRGLTLPGALQGVVFYLYPEPARLADPQVWMEAGAQIF 267

  Fly   327 FSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGL 391
            ||...|..:|..|.||||:|.||||.:|....:|..||.:|||.:|||||:||..|...|::|..
Zfish   268 FSYALGTASLTVLGSYNKYNYNCYRSSLWLCLLNSSTSVIAGFAVFSVLGFMAQKQGLPIEEVAE 332

  Fly   392 EGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGR--RRE 454
            .||||.||.||:|:|.|.....|:..||:|:|.||||:.|..:|..:|::.|.:|.|:.:  |||
Zfish   333 SGPGLAFIAYPQAVAMMPFPQLWAACFFIMIILLGLDTQFVAMEVFMTSVIDLFPTVLRKAGRRE 397

  Fly   455 LFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYG-PGLAILFVVFVEAAGVFWFYGVDRFSSDVEQ 518
            :|:||...|.|...|..:|.||:.:....:.|. .|..:||:...|:..:.|.:|.::....:|.
Zfish   398 IFLLLFCLFCFFGQLVMVTEGGMYVFQLFDYYACSGACLLFLCVFESLAMGWVFGAEKMFGIIED 462

  Fly   519 MLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYY-YPDWSYQVGWAVTCSSVLCIPM 582
            |..|:|..::.:||.|::|:..|..|:.|::.||.:....:| ||||:|.:||.:..||:|.:|.
Zfish   463 MTNSRPNYWFMLCWKYLTPIVSLASFVCSLVKYKPLTFNRWYVYPDWAYVLGWLLALSSILLVPG 527

  Fly   583 YIIYKFFFASKGGCRQRLQESFQPEDN 609
            :.:.: .||.||..:||......|:.|
Zfish   528 WALGR-MFAGKGSIKQRWSHLCSPDTN 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	231/543 (43%)
si:ch211-132b12.2	NP_001038688.1	SLC6sbd-TauT-like	11..550	CDD:271387	231/542 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820