DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and slc6a6b

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001032750.1	Gene:	slc6a6b / 569098	ZFINID:	ZDB-GENE-030131-3077	Length:	625	Species:	Danio rerio

Alignment Length:	563	Identity:	254/563 - (45%)
Similarity:	354/563 - (62%)	Gaps:	31/563 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFH 138
            ||.|..|.:|||:|.|..|.|||||||||:||:|||||||:||.:||..||||:|::|:|||||.
Zfish    41 REKWASKLDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEVALGQFT 105

  Fly   139 RCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTEN 203
            ..|.::.|:::||...|:|||..:|...:.:||..|:.|.:||||..|..:|||.||:|.|||||
Zfish   106 SEGGITCWEKLCPIFTGIGYASIVIVSLLNIYYIVILAWGLYYLFQCFQPELPWASCNNKWNTEN 170

  Fly   204 CMQVT---------SENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVY 259
            |::.|         :.|.|.. |||..||:||.||..  .:|::.:|.||..||||:..::|:.:
Zfish   171 CVEDTLRRNKTLWAAANATNF-TSPVTEFWERNVLSI--SDGIEEVGHVKWDLALCLLAMWVICF 232

  Fly   260 FSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQ 324
            |.:||||:|.||||:|||..|:|:||:||||||:||||.||||:||.|...:|.:.:|||||.:|
Zfish   233 FCVWKGVKSTGKVVYVTATFPFVMLIVLLVRGVTLPGAAEGIKFYLYPNVTRLGDPEVWIDAGTQ 297

  Fly   325 IFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKV 389
            ||||.....|.:.:|.||||:..|||||.|:...:|..|||::||.||||||:||..|...|..|
Zfish   298 IFFSYAICLGAMTSLGSYNKYKYNCYRDCLLLGGLNSATSFVSGFAIFSVLGFMAQEQGVDIADV 362

  Fly   390 GLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVI--GRR 452
            ...||||.||.||:|:..|....||:|:||:||:.|||||.|..:|..||:|.|.||..:  |.|
Zfish   363 AESGPGLAFIAYPKAVTMMPLPTFWAILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYR 427

  Fly   453 RELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVY-GPGLAILFVVFVEAAGVFWFYGVDRFSSDV 516
            ||:|:.::....:|..|..:|.||:.:....:.| ..|:.:|:|.|.|...|.|.||.|.|...:
Zfish   428 REIFIAIVCFVSYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECIAVAWVYGADNFYDAI 492

  Fly   517 EQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEM-LGEEYYYPDWSYQVGWAVTCSSVLCI 580
            |:|:|.:|..:.:..||.::|...:..||||::.|..: ..:.|.|||||..|||.:..:|::||
Zfish   493 EEMIGYRPNPWMKWSWTVVTPFLCVGCFIFSLVKYAPLRYNKIYEYPDWSIGVGWTLALASMICI 557

  Fly   581 PMYIIYKFFFAS--------------KGGCRQRLQESFQPEDN 609
            ||.::.|...:.              :||.....|| :||:.|
Zfish   558 PMVVVIKIIQSDGPLIERIKAVAAPVRGGASSCPQE-YQPKSN 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	252/559 (45%)
slc6a6b	NP_001032750.1	SLC6sbd_TauT	41..582	CDD:271398	247/543 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930