DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and slc6a1l

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_021330952.1	Gene:	slc6a1l / 568985	ZFINID:	ZDB-GENE-041210-296	Length:	578	Species:	Danio rerio

Alignment Length:	561	Identity:	255/561 - (45%)
Similarity:	363/561 - (64%)	Gaps:	14/561 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFH 138
            |.:|..|.:|||:.:|:|:.|||||||||:|.:|||||||:||...|:|.|:|||.:|.||||:.
Zfish    27 RGSWKGKFDFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFTTLVFAGIPLFLLETALGQYT 91

  Fly   139 RCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTEN 203
            ..|.|.:||.| |.:||||.|..::..::.:||..||.||:||||:|..::|||.:|||||||:.
Zfish    92 SVGGLGVWKLI-PMMKGVGLAAVVLSFWLNIYYIIIIAWALYYLFSSLKAELPWQTCDNPWNTDR 155

  Fly   204 CMQVTSENFTELATSPAKEFFERKVLESYKGNGLDFMG----PVKPTLALCVFGVFVLVYFSLWK 264
            |....|...|...:|...||:||.:.:  ..|||:..|    |:..||||.    ::|||||:||
Zfish   156 CFSNYSLLDTTNLSSAVTEFWERNMHQ--LTNGLEEPGELRWPLVGTLALS----WILVYFSIWK 214

  Fly   265 GVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSL 329
            ||...||||:.:|..||.:|.||..|||:||||.:|:.:|:||.::||..|:||:|||:|||||.
Zfish   215 GVEWTGKVVYFSATYPYFMLFILFFRGVTLPGAIDGVLFYITPNFNKLLKSEVWLDAATQIFFSY 279

  Fly   330 GPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGP 394
            |.|.|:|:||.|||.||||.|||::|...||..||..||.||||::|:|:|:.|..|:::...||
Zfish   280 GLGLGSLIALGSYNSFNNNVYRDSVIVCCINSCTSMFAGIVIFSIVGFMSYITKRPIEELAASGP 344

  Fly   395 GLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLL 459
            ||.|:.||:|:..:..|..|:|:||.||:.|||||.|..:|..||||.||||.|:.:|:::|:|:
Zfish   345 GLAFLAYPQAVTQLPMSSLWAILFFSMLMMLGLDSQFCTVEGFITALMDEYPTVLRKRKKIFILI 409

  Fly   460 LLAFIFLCALPTMTYGGVVLVNFLNVY-GPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSK 523
            :....|:.....:|.||:.:....:.| ..|:.:||:||.|...:.||||.::|..::|:|:|.:
Zfish   410 VCLVSFIIGFSNITQGGLYVFKLFDYYSASGMCLLFLVFFETISIAWFYGAEKFYKNIEEMIGYR 474

  Fly   524 PGLFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKF 588
            |..||:.||.|.:|...|.:|.||.:....:...:|.||.|...|||.::.||::.||.|||| .
Zfish   475 PCGFWKQCWIYFTPTICLGVFTFSAIEMTPLTLGKYVYPAWGQGVGWLMSLSSMVLIPGYIIY-M 538

  Fly   589 FFASKGGCRQRLQESFQPEDNCGSVVPGQQGTSVXHDHAQV 629
            ||::||..|||..:..:|.:...|.|.....|.:  |.|.|
Zfish   539 FFSTKGNIRQRWHKMTKPTELTTSDVNDLTHTGIM-DEASV 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	248/537 (46%)
slc6a1l	XP_021330952.1	SLC5-6-like_sbd	15..558	CDD:320982	249/538 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820