DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerT and slc6a16b

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001103944.1	Gene:	slc6a16b / 567809	ZFINID:	ZDB-GENE-070424-95	Length:	676	Species:	Danio rerio

Alignment Length:	719	Identity:	218/719 - (30%)
Similarity:	339/719 - (47%)	Gaps:	149/719 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 ERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALG 135
            |..|:.|..|.|:.||.:||:|.|||||||||:|:|||||||::.|.:.:...|:|||::|||.|
Zfish    30 ETARDGWDSKVEYFLAQVGFSVGLGNVWRFPYLCHQNGGGAFILLYVVLMALVGVPLFFLELAAG 94

  Fly   136 QFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWN 200
            |..|.|.:.:|:.|.|.|.|:||:.|::..::.:|||.||||:::||..||...|||..|....|
Zfish    95 QSIRQGSIGVWRHISPKLVGIGYSSCVVCFFVALYYNVIIGWSIFYLGNSFQYPLPWEKCPTEGN 159

  Fly   201 T--ENCMQVTSENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLW 263
            :  :.|          .|:||...|:.||.|:.  .:.:|..|.....|..|:...:|:|..:::
Zfish   160 STVKEC----------AASSPTAYFWYRKALDI--TDSIDETGEFNFILTGCLLAAWVIVCLAMY 212

  Fly   264 KGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFS 328
            ||::|:|||::.:::.|||||:..|:|||:|.||.||||:...|......:.:||..||:|:||:
Zfish   213 KGIKSSGKVMYFSSVFPYVVLLCFLIRGVTLDGASEGIKFMFYPRLEIWADVQVWRQAATQVFFA 277

  Fly   329 LGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAY------------- 380
            ||.|||:::|.||||..||||:|||...|.:|.:||.||..|:|:|||:.|.
Zfish   278 LGLGFGSVIAYSSYNPRNNNCHRDAFTVSGVNFMTSVLATLVVFAVLGFRAKTIAAECVKRNLKA 342

  Fly   381 -------------------VQKTSID-----------------------------KVGLEGPGLV 397
                               |:..|:|                             :.|:|..||.
Zfish   343 LLKVTSSAPLPVLSINASDVESISLDEYANWYSTQGMELSISDYNITACSLEDELRQGVEETGLA 407

  Fly   398 FIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLA 462
            ||.:.||:....||.|||.:|||||:.|||.:.||.:..::|.|.|.: :.:...:.:|.:....
Zfish   408 FIAFTEAMTLFPGSPFWSALFFLMLLNLGLSTMFGTMAGILTPLTDTF-KTLRNHKLIFTICSCT 471

  Fly   463 FIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLF 527
            ..|:..|......|...|...:.|...|.::.||..:...|.|.||.|||..|::|||.....:.
Zfish   472 VGFVIGLVFTQRCGNYFVTMFDDYSATLPLIIVVIFQTISVSWVYGADRFLEDLKQMLNRPVPVI 536

  Fly   528 WRICWTYISPVFLLTIFIFSIMGYKEMLGEEYY--------------YPDWSYQVGWAVTCSSVL 578
            ::..|.::.|:.:|.:...|::  |.:|....|              ||||:..|...:...:.|
Zfish   537 YKYLWKFVCPIAMLGLLGASLL--KMILKRPEYSAWNREKASKEDLPYPDWALAVLIILIIIASL 599

  Fly   579 CIPMYIIYKFFFASKGGCRQRLQESFQPEDNCGSVVPGQQGTSVXHDHAQVHVNIRTSCTSIKIY 643
            .:|:..|:....       :||.:|  |.|......|
Zfish   600 PVPIGYIHSLLL-------ERLGQS--PADTEARYTP---------------------------- 627

  Fly   644 NLNCSSNSNSLSPTTSGAEGRSCYSTNLNCNHSCPSEDQYRSRNHQQQQQQHHHHHHHQHQHRIS 708
               |::....|:|.::                ..||.|...| :|...:..|:.|..:.|...:.
Zfish   628 ---CATTDTDLTPLST----------------LPPSRDDLNS-SHPLLEGNHNSHLQNGHIESVE 672

  Fly   709 SDII 712
            |.::
Zfish   673 SSVL 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	202/609 (33%)
slc6a16b	NP_001103944.1	SLC6sbd-B0AT-like	33..607	CDD:271364	198/588 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910