Protein Alignment SerT and Slc6a14

DIOPT Version :9

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_064433.3
• Gene: Slc6a14 / 56774
• MGIID: 1890216
• Length: 638
• Species: Mus musculus
• Alignment Length: 607
• Identity: 248/607 - (40%)
• Similarity: 363/607 - (59%)
• Gaps: 48/607 - (7%)

  Fly    49 KVTDPLAPKLANNERILVVSVTE-RTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAF 112
            |||       |::|...|....| :.|..|.:|:::||:::|:||.|||||||||:.|.||||||
Mouse    17 KVT-------ASSENFHVGENDENQERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAF 74

  Fly   113 LVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGW 177
            |:||.:.|...|||||::|.:||||...|.:|:| ||.|..:|||..:.||.:::.:|||.||.:
Mouse    75 LIPYAIMLALAGLPLFFLECSLGQFASLGPVSVW-RILPLFQGVGITMVLISVFVAIYYNVIIAY 138

  Fly   178 AVYYLFASFTSKLPWTSCDNPWNTENCMQ----------------------VTSENFTELATS-- 218
            ::|||||||.|.|||.:|.: |..|||.:                      |.:.|.|.|..|
Mouse   139 SLYYLFASFQSVLPWANCSS-WADENCSRTPIVTGCNVSIGAGEMFMNISWVNTNNLTCLNGSEV 202

  Fly   219 ------PAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTA 277
                  |:::::::..|:  :.:|:|..|.|...||||:...:::|..:|:||::|:||||:.||
Mouse   203 FRPGQLPSEQYWDKVTLQ--RSSGMDETGVVVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTA 265

  Fly   278 LAPYVVLIILLVRGVSLPGADEGIKYYLTPE--WHKLKNSKVWIDAASQIFFSLGPGFGTLLALS 340
            |.|||||:|||:||.:|.||.:||.||:..:  :.||:.::||.|||:|||:||...:|.|:|||
Mouse   266 LFPYVVLLILLIRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALS 330

  Fly   341 SYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAI 405
            ||||||||||.||:|....|||||..|||.|||:||:||::....:.:|...|..|.||.||||:
Mouse   331 SYNKFNNNCYSDAIIVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEAL 395

  Fly   406 ATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALP 470
            |.:....||||:||.||:||||||.|..:|.:.|...|.:|:.:.|.|....|.....:||..|.
Mouse   396 AQLPAGPFWSILFFFMLLTLGLDSQFASIETITTTFQDLFPKAMKRMRVPITLGCCLILFLLGLL 460

  Fly   471 TMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLF---WRICW 532
            .:|..|:..|:.::.:..|..||....:|.||:.|.||.:||..|:|.|:|:|..:|   ||.||
Mouse   461 CVTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWIFWLWWRACW 525

  Fly   533 TYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCR 597
            ..|:|:.|..|.::|::.:......:..||||...:||.:....::.||:..|.|...| :|...
Mouse   526 FVITPILLSAILVWSLVKFHRPDYADIPYPDWGVALGWCMIIFCIIWIPIMAIIKIVQA-EGNIL 589

  Fly   598 QRLQESFQPEDNCGSVVPGQQG 619
            ||:....:|..|.|..:...:|
Mouse   590 QRIISCCRPASNWGPYLEKHRG 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	237/567 (42%)
Slc6a14	NP_064433.3	SLC5-6-like_sbd	36..637	CDD:294310	241/581 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	618..638

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820