DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerT and slc6a8

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001314797.1	Gene:	slc6a8 / 567544	ZFINID:	ZDB-GENE-071024-2	Length:	652	Species:	Danio rerio

Alignment Length:	571	Identity:	256/571 - (44%)
Similarity:	361/571 - (63%)	Gaps:	38/571 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 VSVTER------TRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGL 125
            :|..|:      .||||.::.:|:::.:||||.|||||||||:||:||||.||:||.||:..||:
Zfish    51 ISAVEKKREGYPERETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLFIFLGGI 115

  Fly   126 PLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKL 190
            |:|::|:|||||.:.|.:::| .|.|..||:|||..:|..:...||..::.|..||...||.:.|
Zfish   116 PIFFLEIALGQFMKAGSINVW-NIAPLFKGLGYASMVIVFFCNTYYIMVLAWGFYYFIKSFNATL 179

  Fly   191 PWTSCDNPWNTENCMQV--------------TSENFT--ELAT--SPAKEFFERKVLESYKGNGL 237
            ||::||||||||||:::              |..|.|  |||.  ||..||:|.|||..  .:||
Zfish   180 PWSTCDNPWNTENCIEIFRQGDCKNGTIGNSTFGNLTCEELANGRSPIIEFWENKVLNI--SDGL 242

  Fly   238 DFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIK 302
            |..|.|...|.||:..|:|:|||.:||||:|.||:|:.||..|||||||||||||:||||.:||.
Zfish   243 DEPGAVNWELMLCLLAVWVMVYFCVWKGVKSTGKIVYFTATFPYVVLIILLVRGVTLPGAYDGIL 307

  Fly   303 YYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLA 367
            ||:.|:|.||..::|||||.:|||||...|.|.|.||.|||:|||:||:||.:.:.||..|||.|
Zfish   308 YYVKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNDCYKDAFVLALINSGTSFFA 372

  Fly   368 GFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFG 432
            |||:||:||:||..|...|.||...||||.||.||:|::.|..:..|:.:||:||:.|||||.|.
Zfish   373 GFVVFSILGFMASEQGVDISKVAESGPGLAFIAYPKAVSMMPVAPVWAALFFIMLLLLGLDSQFV 437

  Fly   433 GLEAMITALCDEYPRVIGR-----RRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVY-GPGLA 491
            |:|..:|.:.|.:|   |:     :||:.|.:.....|:..|..:|.||:.:....:.| ..|:.
Zfish   438 GVEGFVTGILDLFP---GKYYMRYQREIAVAICCLLCFIIDLSMVTQGGMYVFQLFDYYSASGMT 499

  Fly   492 ILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEM-L 555
            :|:..|.|...|.|.||.|||..|:.:|:|.:|..:.:.||:.|:|...:.||:|.::.||.: .
Zfish   500 LLWQAFWECVVVAWVYGADRFMDDIARMIGYRPFPWMKWCWSIITPCVCMGIFLFHLLNYKPLTY 564

  Fly   556 GEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQESFQP 606
            ...|.||.|...:||.:..||:||||:.::|| ...:||..::|.:...:|
Zfish   565 NNVYVYPWWGEVIGWCLALSSMLCIPVSLVYK-LSGAKGTFKERWENLTKP 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	254/558 (46%)
slc6a8	NP_001314797.1	SLC6sbd_CT1	64..652	CDD:271397	254/558 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830