DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerT and slc6a2

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_009301625.1	Gene:	slc6a2 / 565776	ZFINID:	ZDB-GENE-110408-4	Length:	625	Species:	Danio rerio

Alignment Length:	607	Identity:	306/607 - (50%)
Similarity:	417/607 - (68%)	Gaps:	36/607 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EDDG-DHTTPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVDLGNVWRFPY 102
            |.:| .:|..:.|..|      ::......|..|..|||||:|.:|||:||||||||.|||||||
Zfish    34 EQNGVQYTNSSVVASP------SSRACTSASGEEIERETWGKKMDFLLSVIGFAVDLANVWRFPY 92

  Fly   103 ICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYM 167
            :||:|||||||:||.|||...|:|||||||||||::|.|..::|| |||..|||||.:.:|.:|:
Zfish    93 LCYKNGGGAFLIPYVLFLFIAGMPLFYMELALGQYNREGAATLWK-ICPVFKGVGYTVIVIALYV 156

  Fly   168 GMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQVTSENFTELA---------TSPAKEF 223
            |.|||.||.|::|||:||.||:|||..|:||||:.||.:....|.|.|.         .:||.||
Zfish   157 GFYYNVIIAWSLYYLYASLTSELPWLHCNNPWNSPNCTEPKDINGTVLGNGTSYAKYKNTPAAEF 221

  Fly   224 FERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILL 288
            :||.||.|::..|:..:|..:..|.:|:..|..::||||||||:|:||||::||..||:||::||
Zfish   222 YERGVLHSHESKGIGDLGLPRWELTICLVVVAFILYFSLWKGVKSSGKVVYITATMPYIVLLVLL 286

  Fly   289 VRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDA 353
            :||::||||..||:.||..:..||.|.:||||||:|||||||.|||.|:|.||||||||||||||
Zfish   287 IRGITLPGAMNGIRAYLHIDLKKLNNPQVWIDAATQIFFSLGAGFGVLIAFSSYNKFNNNCYRDA 351

  Fly   354 LITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIF 418
            ::||:|||:|||.:||.|||||||||...|.:|..|..||.||||::|||||:|:.|:.|::|:|
Zfish   352 ILTSTINCVTSFFSGFAIFSVLGYMAEQHKVNIKDVATEGAGLVFVIYPEAISTLPGATFFAIVF 416

  Fly   419 FLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFL 483
            |:||:|||:||:.||:||::|.|.|:: :::.|.|:||....:...||.||..:|.||:.::..|
Zfish   417 FIMLLTLGIDSSMGGMEAVLTGLSDDF-KILKRNRKLFTFATVVGTFLMALLCVTNGGIYVLTLL 480

  Fly   484 NVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSI 548
            :.|..|.:|||.|..||.||.|||||||||.|:|:|:|.|||::||:||.::||.|||.:.|.||
Zfish   481 DKYAAGTSILFGVLFEAIGVSWFYGVDRFSEDIERMMGFKPGIYWRLCWKFVSPAFLLLVVIASI 545

  Fly   549 MGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQESFQPEDNCGSV 613
            :....:..:||.:|.|:..:||::..||:|.:|.|.||| ||:.....::||.....||
Zfish   546 VTSGRLTYDEYVFPYWADMLGWSIALSSMLFVPFYAIYK-FFSVPSSFKERLAYCVTPE------ 603

  Fly   614 VPGQQGTSVXHDHAQV-HVNIR 634
                      |:|..| ..|:|
Zfish   604 ----------HEHHLVAEGNVR 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	292/541 (54%)
slc6a2	XP_009301625.1	SLC5-6-like_sbd	64..623	CDD:294310	299/571 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.830