DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerT and slc6a7

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_005161359.1	Gene:	slc6a7 / 562050	ZFINID:	ZDB-GENE-070112-1492	Length:	652	Species:	Danio rerio

Alignment Length:	691	Identity:	258/691 - (37%)
Similarity:	382/691 - (55%)	Gaps:	73/691 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AGAAATTGRSNPAPWSDDKESPNNEDDSNEDDGDHTTPAKVTDPLAPKLANNERILVVSVTERTR 74
            :.|...|..:..||.:....:|:.|:.::::....:..|..:.|  |..|.:      ...:..|
Zfish    15 SAAEMPTEEARTAPGNGVITTPSTENPAHQNGAVSSPVASQSQP--PSSAAS------PPAQPPR 71

  Fly    75 ETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHR 139
            :.||.|.||||:.||:.|.|||||||||:||:||||.||:||.:.|.|.|:|||.|||:|||:..
Zfish    72 DQWGGKYEFLLSCIGYCVGLGNVWRFPYLCYRNGGGVFLIPYFIMLFFTGMPLFLMELSLGQYGA 136

  Fly   140 CGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENC 204
            .|.:::|| .||.|||:|..:..:...:.:|||.||.|..|||.:||.|.||| |||...|...|
Zfish   137 AGPITVWK-CCPLLKGIGIGMLCVSTLVCLYYNVIIAWTFYYLGSSFQSPLPW-SCDALQNIALC 199

  Fly   205 MQVTSENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSA 269
                 .|.|....||::.|:..|||......||...|||:..||||:...:::::..:.||:.|:
Zfish   200 -----ANKTNSTQSPSEVFWNEKVLGVVHSTGLSDPGPVRWPLALCLLAAWIIIFLCMLKGIHSS 259

  Fly   270 GKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFG 334
            ||||:|||..||.||::|::||.:|.|:.:|:.:||||:|.:|.:::||.|||||||:|||.|.|
Zfish   260 GKVVYVTATFPYFVLLVLIIRGATLEGSLDGVAFYLTPKWDQLADAQVWNDAASQIFYSLGIGVG 324

  Fly   335 TLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFI 399
            .||:::|||||:||..||.:|.:..||.|||.|||.|||:||:||:.:...:|||...||||.|:
Zfish   325 GLLSMASYNKFDNNVIRDTIIITIGNCSTSFFAGFAIFSILGHMAFKKGVPVDKVADSGPGLAFV 389

  Fly   400 VYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIG--RRRELFVLLLLA 462
            .||||:|.:.|||||||:|||||..||:|:.||.:|.:.||:.||:|::..  :.:.||:.:|..
Zfish   390 AYPEALALLPGSVFWSILFFLMLFMLGVDTLFGNMEGICTAVLDEFPQLRSNLKHKTLFLAVLCF 454

  Fly   463 FIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPG-- 525
            ..:|..|..:|.||:.....::.:.....::.:......|:.:||||::|..|:..|:...|.
Zfish   455 SFYLMGLLLITDGGIYWFTLIDSFSTSFGLIIITLFMCIGISFFYGVNQFCQDIVDMICRCPPWC 519

  Fly   526 ----LFWRICWTYISPVFLLTI---FIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMY 583
                |:::.||...:| ||||.   :||..|....:....|.||.|...:|   .|...||....
Zfish   520 TKMLLYFKACWVVFTP-FLLTFILTYIFIEMYRTSLRYGSYVYPIWGKALG---VCMGALCCLQI 580

  Fly   584 IIYKFFFASK--GGCRQRLQESFQPEDNCGSVVPGQQGTSVXHDHAQVHVNIRTSCTSIKIYNLN 646
            :|:.....||  |..:.|.::|.:|                              ..|.::.|:|
Zfish   581 LIWAIVAISKESGTLKDRFKKSIRP------------------------------LNSWRVNNIN 615

  Fly   647 CSSNSNSLSPTTSGAEGRSCYSTNLNCNHSCPSEDQYRSRN 687
            .||....:.|.|  .||.  ::.||       :|..|...|
Zfish   616 SSSQEQHVEPHT--IEGP--FTVNL-------TEADYTGMN 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	233/545 (43%)
slc6a7	XP_005161359.1	SLC5-6-like_sbd	71..610	CDD:294310	235/579 (41%)
slc6a7	XP_005161359.1	PotE	<235..564	CDD:223605	138/329 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820