DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and SLC6A15

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_877499.1	Gene:	SLC6A15 / 55117	HGNCID:	13621	Length:	730	Species:	Homo sapiens

Alignment Length:	724	Identity:	231/724 - (31%)
Similarity:	360/724 - (49%)	Gaps:	133/724 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SNEDDGDHT--TPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVDLGNVWR 99
            ||||..|..  |...:.|....|..:.|.   .|..|..|..|..|.:::||.:||:|.||||||
Human    25 SNEDAADDAFKTSELIVDGQEEKDTDVEE---GSEVEDERPAWNSKLQYILAQVGFSVGLGNVWR 86

  Fly   100 FPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLID 164
            |||:|.:|||||:|:||.:.|:..|:|||::||::||..|.|.:.:|..|.|.|.|:|:|.|::.
Human    87 FPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVC 151

  Fly   165 IYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQVTSENFTE---LATSPAKEFFER 226
            .::.:|||.||||:::|...||...|||..|.       .::..|..|.|   ..:|....::.|
Human   152 YFVALYYNVIIGWSLFYFSQSFQQPLPWDQCP-------LVKNASHTFVEPECEQSSATTYYWYR 209

  Fly   227 KVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRG 291
            :.|..  .:.:...|.:...:.:|:...:|:|..::.||::|:||:::.::|.||||||..|:|.
Human   210 EALNI--SSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRA 272

  Fly   292 VSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALIT 356
            ..|.|:.:||::..||:...:...|||.:||:|:||:||.|||.::|.|||||.:|||:.||::.
Human   273 FLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLV 337

  Fly   357 SSINCLTSFLAGFVIFSVLGYMAYV-------QKTS----------------------------- 385
            |.||..||.||..|:|:|||:.|.|       |.:.
Human   338 SFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAED 402

  Fly   386 -------IDKV---------------------GLEGPGLVFIVYPEAIATMSGSVFWSIIFFLML 422
                   |.||                     .::|.||.||.:.||:.....|.|||::|||||
Human   403 YHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 467

  Fly   423 ITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYG 487
            :.|||.|.||.:|.::|.:.|.: :|   |:|:..::.....|...|..:...|...|...:.|.
Human   468 VNLGLGSMFGTIEGIVTPIVDTF-KV---RKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYS 528

  Fly   488 PGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIM--- 549
            ..|.:|.||.:|...|.:.||:|:|..|::.|||..|..::...|.||||:.||::.|.|::
Human   529 ATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMG 593

  Fly   550 ----GY----KEMLGEEYY-YPDWSYQVGWAVTCSSVLCIP-MYIIYKFFFASKGGCRQRLQESF 604
                ||    ::...||:. ||.|...|..::...::|.:| ::|:.:|...
Human   594 LSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLI------------- 645

  Fly   605 QPEDNCGSVVPGQQGTSVXHDHAQV---HVNIRTSCTSI---KIYNLNCSSN-------SNSLSP 656
              :|:.|::      .||.:...:|   .||:....||:   ||.:...|.|       ..|.||
Human   646 --DDSSGNL------ASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSP 702

  Fly   657 TTSGA-EGR 664
            |...| .||
Human   703 TLDTAPNGR 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	200/612 (33%)
SLC6A15	NP_877499.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..60		5/21 (24%)
SLC6A15	NP_877499.1	SLC6sbd_SBAT1	61..640	CDD:212091	199/591 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820