DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerT and slc6a9

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_005163551.1	Gene:	slc6a9 / 494490	ZFINID:	ZDB-GENE-050105-3	Length:	653	Species:	Danio rerio

Alignment Length:	599	Identity:	253/599 - (42%)
Similarity:	365/599 - (60%)	Gaps:	48/599 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 HTTPAKVTD-----PLAP-KLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVDLGNVWRFPY 102
            :||.|.:.|     |..| |...|.|          |..||.:.||:|..:|:||.|||||||||
Zfish     5 NTTAAVMADQNGAVPGEPVKRDENSR----------RGNWGNQIEFVLTSVGYAVGLGNVWRFPY 59

  Fly   103 ICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYM 167
            :||:||||||:.||.:.|:|.|:|||::||:.|||...|||.:|| :.|..|||||.:.::..|:
Zfish    60 LCYRNGGGAFMFPYFIMLVFCGIPLFFLELSFGQFTSLGCLGVWK-VSPMFKGVGYGMMVVSTYI 123

  Fly   168 GMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQVTS---------------ENFTELA- 216
            |:|||.:|..|.||.|.|.|:.||||.|:|||||.:|..|.|               ...||:.
Zfish   124 GIYYNVVICIAFYYFFMSMTNLLPWTYCNNPWNTPDCSGVVSTHRANATFANMSAVVSGVTEIVN 188

  Fly   217 ----TSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTA 277
                |||::|::...||..  .:|:...|.|:..:..|:...:.:|:..|.:||:|:||||:.||
Zfish   189 RTKRTSPSEEYWRNYVLNI--SDGIGNFGEVRLPILGCLAVSWFVVFLCLIRGVKSSGKVVYFTA 251

  Fly   278 LAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSY 342
            ..|||||.||.:||::|.||..||||||||:|.|:.::|||.|||||||:|||..:|.|:.::||
Zfish   252 TFPYVVLTILFIRGITLDGAISGIKYYLTPQWQKILDAKVWGDAASQIFYSLGCAWGGLITMASY 316

  Fly   343 NKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIAT 407
            |||:|||:||::|.|..||.||..|||||||:||:||:.....:.:|...||||.|:.||||:..
Zfish   317 NKFHNNCFRDSIIISVTNCGTSVYAGFVIFSILGFMAHHLGVDVSEVADHGPGLAFVAYPEALTL 381

  Fly   408 MSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGR----RRELFVLLLLAFI-FLC 467
            :..|..||::||.|||.|||.:.|..||.::||:.||    ||.    :.:.:|.|.:|.| ||.
Zfish   382 LPISPLWSLLFFFMLILLGLGTQFCLLETLVTAVVDE----IGTDWIIKNKTYVTLGVAIIGFLL 442

  Fly   468 ALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICW 532
            .:|..|..|:..:..::.|....:::.:..:....:.:.||...:..|||.|||..|.:|:||||
Zfish   443 GVPLTTQAGIYWLLLMDNYAASFSLVIISCIMCICIMYVYGHKNYFKDVEMMLGFPPPIFFRICW 507

  Fly   533 TYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCR 597
            .|:||..:..|.||:::.||.:...:|.||.||..:|:|:..|||:|||:|.::|...:......
Zfish   508 RYVSPFIITFILIFTVIQYKPITYNDYVYPGWSLVIGFAMALSSVICIPIYALFKIAMSEGSTFL 572

  Fly   598 QRLQESFQPEDNCG 611
            :||:.|.:|:.:.|
Zfish   573 ERLKNSVKPDPDWG 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	242/557 (43%)
slc6a9	XP_005163551.1	SLC6sbd_GlyT1	15..598	CDD:212067	249/589 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820