Protein Alignment SerT and slc6a5

DIOPT Version :10

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_001009557.1
• Gene: slc6a5 / 494450
• ZFINID: ZDB-GENE-050105-2
• Length: 786
• Species: Danio rerio
• Alignment Length: 679
• Identity: 263/679 - (38%)
• Similarity: 394/679 - (58%)
• Gaps: 74/679 - (10%)

  Fly     2 DRSGSSDFAGAAATTGRSNPAPWSDDKESPNNEDDSNEDDGDHTTPAKVTDPLAPKLANNERILV 66
            |..|..|     |:||::.....|:::.:.....:.|...||.|:.::.|..|...  .|..:|.
Zfish    90 DSVGKMD-----ASTGKATSDFMSNNQSAVRIAAEHNNSTGDWTSMSQTTIILGTD--GNTSVLP 147

  Fly    67 VSVT----------------------ERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGG 109
            .:||                      .:.|..|..|.:|:|:::|:||.|||||||||:.:||||
Zfish   148 GTVTGPPTDDTGRLFQDDDDDDGGDENKARGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFQNGG 212

  Fly   110 GAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTI 174
            ||||:||.:.|...|:|:|.:|::||||...|.:|:||.| |||:|.|.|:.:|.:.:.:|||.|
Zfish   213 GAFLIPYLIMLGLAGIPIFLLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNII 276

  Fly   175 IGWAVYYLFASFTSKLPWTSCDNPWNTENC----------------------------------- 204
            :.|.:||||||....|||.:|.|.|||..|
Zfish   277 MCWTLYYLFASLKETLPWATCKNEWNTVECKDKDMLLLDTCILRDRNITSIKNTTFCLSANVVGN 341

  Fly   205 ----MQVTSENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKG 265
                :.||.:|.|.:  ||::|:|:..||...|  |:::.|.::..||.|:|..:::||.||.||
Zfish   342 LSKLLNVTVDNKTYV--SPSEEYFKYNVLHISK--GIEYPGDIRWPLAACLFLAWLIVYASLAKG 402

  Fly   266 VRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLG 330
            ::|:||||:.||..|||||:|||:|||:||||..||.|::||:|.||.::|||.|||:||||||.
Zfish   403 IKSSGKVVYFTATFPYVVLVILLIRGVTLPGAGSGILYFITPKWEKLNDAKVWKDAATQIFFSLS 467

  Fly   331 PGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPG 395
            ..:|.|:.|||||||:||||||.||.:..|..||..||||||||:|:||:..|..|:.|..||||
Zfish   468 AAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAHELKVPIESVADEGPG 532

  Fly   396 LVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLL 460
            :.|:|||||:..:..|.||:|||||||:|||||:.|..:|.::|::.||:|:.:.:.:..|.|:.
Zfish   533 IAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSVSDEFPKYLRKHKPQFTLVC 597

  Fly   461 LAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPG 525
            ....|:...|.:|..|:.::..::.:....:::.:...|..|:.:.||:.||..|:|.|:|.:|.
Zfish   598 CLSFFVLGFPMITESGMYMLQLVDTFAASYSLVIIAIFELVGISYIYGLQRFCEDIEMMIGFQPN 662

  Fly   526 LFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFF 590
            .|||:||.:::|..|..|...|:..:|.|..|:|.||:||..:||.:...||:.||:....|...
Zfish   663 KFWRVCWAFVTPTILTFILALSLYQWKVMTYEDYTYPNWSMVLGWLMVICSVIWIPIMFAIKMHL 727

  Fly   591 ASKGGCRQRLQESFQPEDNCGSVVPGQQG 619
            | .|...:||:....|:.:.|..:...:|
Zfish   728 A-PGSLIERLKLVCSPQPDWGPFLMKHRG 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	243/571 (43%)
slc6a5	NP_001009557.1	SLC5-6-like_sbd	177..775	CDD:444915	246/585 (42%)