DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and blot

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster

Alignment Length:	798	Identity:	169/798 - (21%)
Similarity:	288/798 - (36%)	Gaps:	172/798 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ATTGR--SNPAPWSDDKESPNNEDDSNEDDGDHTTPAK----------VTDPLAPKLANNERILV 66
            ||:||  |:......|..:..:|......|.||...:|          :|      .|:|.::|.
  Fly   146 ATSGRISSSGIVTLSDSNNTLSEIQGGYHDMDHDAVSKNFSISASAHNIT------TASNAKLLP 204

  Fly    67 VSVTERTRETWGQKAEFLLAVIGFAVDLGNVWRFP-----YICYQNGGGAFLVPYCLFLIFGGLP 126
            ....|..::|.......|:..:...:...||.|||     |      |.|:||||.:.|...|||
  Fly   205 AVEDESNKQTKCSVFRGLVLCLCLNLSYANVVRFPRELDRY------GSAYLVPYVVLLFLVGLP 263

  Fly   127 LFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLID--------IYMGMYYNTIIGWAVYYLF 183
            :..:|:::|||...|....| |..|..||.    |:|.        |::.:  ..::..|...:|
  Fly   264 MVLLEISVGQFLGQGAAHTW-RASPIFKGA----CMISRFASWLSAIWVSL--QAVLALAYIGMF 321

  Fly   184 ASFTSKLPWTSCDNPWNTENCMQVTSENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLA 248
            ||  :.||:..|..|      :::....:....|| .:|..:...|..:..|.|.|     ..||
  Fly   322 AS--NDLPFRECAGP------VKLRLSGYLLTGTS-GQECLQLTFLTPFWRNPLYF-----GLLA 372

  Fly   249 LCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILL---VRGVSLPGADEGIKYYLTPEW- 309
            ..:.|::::|.... ...:...:.::|..|...|:|..|.   ||       :...::|....|
  Fly   373 AGLIGLWIVVMLCT-HNAKILRRSIFVFGLVGLVLLCTLTGWEVR-------NSFSRHYFPELWG 429

  Fly   310 ---HKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVI 371
               :.|..|.:|.:|..|:.||:..|||.|..::....:..:..|.:::....|.|.:.:|
  Fly   430 FDSNLLAESNIWFNALMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIA---- 490

  Fly   372 FSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGS----------VFWSIIFFLMLITLG 426
              |..:|.....:|.....:|....:..:|..   .::||          :..|:|:.|::
  Fly   491 --VTLFMVQFDLSSNGFQNMEELKPLTAIYDR---VLNGSREGDSHLLQHLVPSLIYALII---- 546

  Fly   427 LDSTFGGLEAMITALCDEY--PRVIGRRRELFVLL--LLAFIFLCALPTMTYGGVVLVNFLNVYG 487
                   |.||::.....|  .|::.||....:.|  |:..:...|.|..     ::...|:...
  Fly   547 -------LSAMVSITVAVYTSTRLVPRRPNYVICLIGLVVAVISFAAPKF-----LIARVLDSRL 599

  Fly   488 PGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIF--SIMG 550
            .|..::..:..|...:.|.||.....:|:|..:|......|...|. |.|..|..|.::  :...
  Fly   600 VGTMVVTALVFELIAITWIYGAKNIYTDLEFSIGRPIFRVWMWLWV-ICPAILTGILVWWCADDD 663

  Fly   551 YKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMY--IIYKFFFASKGGCRQRLQESFQPEDNCGSV 613
            ..::|.|  |.|.|:..:........:.|:.::  :.|.||        ..:.|:.:|....|..
  Fly   664 QYDLLAE--YLPRWAPILFVLAVIVIIACVQIFRQVEYNFF--------GMICEASKPAKEWGPA 718

  Fly   614 VP-----GQQGTSVXHDHAQVHVNIRTSCT-----SIKIYNLNCSSNSNSLSPTTSGAEGRSCYS 668
            .|     .:|..|| .|..:....:|...|     |||                      :..||
  Fly   719 DPLARHSWKQWRSVCQDTGRRDFTLRRRGTRDYTHSIK----------------------KGQYS 761

  Fly   669 TNLNCNHSCPSEDQYRSRNHQQQQQQHHHHHHHQHQHRISSDIISSSLRQSHSHSLSLCSVQSNP 733
                      |..:|..:|..|.|...|..|........||...|.|:....:....: ||...|
  Fly   762 ----------SATKYGVQNGGQTQTPMHQQHWKSSTPGNSSPNYSGSMFGDSAIEEDI-SVDKFP 815

  Fly   734 MATTR--IPLAAEDNNCS 749
            ..|.:  :|..|.|...|
  Fly   816 GITQQQYVPFQASDTKQS 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	120/570 (21%)
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	109/500 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910