Protein Alignment SerT and SLC6A17

DIOPT Version :9

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_001010898.1
• Gene: SLC6A17 / 388662
• HGNCID: 31399
• Length: 727
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 212/659 - (32%)
• Similarity: 330/659 - (50%)
• Gaps: 110/659 - (16%)

  Fly    32 NNEDDSNEDDGDHTTPAKVTDPL---------------APKLANNERILVVSVTERTRETWGQKA 81
            |::....|...:|.|.: |.|.|               |.:....::.:...:....|..|..|.
Human     4 NSKVTQREHSSEHVTES-VADLLALEEPVDYKQSVLNVAGEAGGKQKAVEEELDAEDRPAWNSKL 67

  Fly    82 EFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIW 146
            :::||.|||:|.|||:|||||:|.:|||||:||||.:.||..|:|||::|||:||..|.|.:.:|
Human    68 QYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVW 132

  Fly   147 KRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQVTSEN 211
            ..|||.|.|:|::.|::.:::|:|||.||||:::|.|.||...|||:.|  |......:.|..
Human   133 HYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC--PVVRNGSVAVVE-- 193

  Fly   212 FTELATSPAKEFF-ERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWV 275
             .|...|.|..:| .|:.|:.  .:.:...|.:...:.||:...:.:|..::.||::|:|||::.
Human   194 -AECEKSSATTYFWYREALDI--SDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYF 255

  Fly   276 TALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALS 340
            ::|.|||||...||||:.|.||.:||.:..||:..|:.:.:||.:||:|:||:||.|||.::|.|
Human   256 SSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFS 320

  Fly   341 SYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQ----------------------- 382
            ||||.:|||:.||.:.|.||..||.||..|:|:|||:.|.:.
Human   321 SYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSR 385

  Fly   383 ------------------------------------------KTSIDKVGLEGPGLVFIVYPEAI 405
                                                      :..:|| .::|.||.||.:.||:
Human   386 DLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLEDELDK-SVQGTGLAFIAFTEAM 449

  Fly   406 ATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEY--PRVIGRRRELFVLLLLAFIFLCA 468
            .....|.|||::||||||.|||.|..|.:..:.|.:.|.:  |      :|:|.:....|.||..
Human   450 THFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVP------KEMFTVGCCVFAFLVG 508

  Fly   469 LPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWT 533
            |..:...|...|...:.|...|.:..:|.:|...|.|.||..:|..::.:|||.:|..|:...|.
Human   509 LLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWK 573

  Fly   534 YISPVFLLTIFIFSIM-------GY----KEMLGEEY-YYPDWSYQVGWAVTCSSVLCIPMYIIY 586
            ::||:.:..:...||:       ||    ||...|.| |:|:|:..:...:...:.|.||:..:.
Human   574 FVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVL 638

  Fly   587 KFFFASKGG 595
            :.|.....|
Human   639 RHFHLLSDG 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	204/602 (34%)
SLC6A17	NP_001010898.1	SLC6sbd_NTT4	60..648	CDD:271403	204/602 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..727

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820