DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and List

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	196/557 - (35%)
Similarity:	306/557 - (54%)	Gaps:	33/557 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 ERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALG 135
            |:..|.||...|||.:.|..:|.|||:||||||.:|||||.|::||.:.|:..|.|::|:|::||
  Fly    15 EKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLG 79

  Fly   136 QFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWN 200
            ||...|.:..:. :.|.||||.....|.......||::|:...:.:..|||.|:|||:.|...|.
  Fly    80 QFTGRGVVKAFD-MAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWG 143

  Fly   201 TENCMQVTSENFTELATSPAKEFFERKVLESYKG--NGLDFMGPVKPT--LALCVFGVFVLVYFS 261
            |: |....::| :....|||:.:|||::|.....  |||..     |.  |..|:...::::...
  Fly   144 TD-CHDGNAQN-SSGKMSPAQLYFEREILHEVPNIDNGLSL-----PNWQLVACLAIAWLVIGGV 201

  Fly   262 LWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIF 326
            |.:|::|:||..:...:.|||||:|||:|.|:||||.:||.|:..|:|.:|.|..||..|.:|:|
  Fly   202 LIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVF 266

  Fly   327 FSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKT---SIDK 388
            |||...||||:..:|||.||.|.|.|.:|.::::..:|.:||.:.|.:||.:|  ::|   .|..
  Fly   267 FSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLA--RETGNPDIGS 329

  Fly   389 VGLEGPGLVFIVYPEAIATMS-GSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRR 452
            |...|.||.||.||||||... ....::::|||||..||:.||.|....::..:.|::    |.|
  Fly   330 VVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQF----GLR 390

  Fly   453 RELFVLL---LLAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSS 514
            ......|   |....|..::..||.||..::|.::.||.....|.:...|...|.|.|||:||..
  Fly   391 SPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCE 455

  Fly   515 DVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYY---YPDWSYQVGWAVTCSS 576
            |::.|:|.:.|.:||:||.:|:|..:..:.|:.::   :|...||.   ||..::..|..:....
  Fly   456 DIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLL---DMSALEYKGVGYPTLAHVFGCFLATLG 517

  Fly   577 VLCIPMYIIYKFF--FASKGGCRQRLQESFQPEDNCG 611
            ::.:|.:.||..:  ....|...||::.:.:|.|..|
  Fly   518 LIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSDTWG 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	192/548 (35%)
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	180/483 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440746
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850