Protein Alignment SerT and SLC6A18

DIOPT Version :9

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_872438.2
• Gene: SLC6A18 / 348932
• HGNCID: 26441
• Length: 628
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 206/605 - (34%)
• Similarity: 307/605 - (50%)
• Gaps: 102/605 - (16%)

  Fly    52 DPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPY 116
            ||.|..|.:.            |..|..||::||:..||||.|||:|||||:|...||||||:||
Human     8 DPAACDLGDE------------RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPY 60

  Fly   117 CLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYY 181
            .:.|:|.|:|:|::|||:||..|.|.:.:|..|.|.|.|||.....:...:.:|||||:.|.::|
Human    61 VIALVFEGIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWY 125

  Fly   182 LFASFTSKLPWTSCDNPWN----TENCMQVTSENFTELATSPAKEFFERKVLESYKGNGLDFMGP 242
            |..||...|||:||....|    .|.|.          .:|....|:.|:.|....  .::..|.
Human   126 LLNSFQHPLPWSSCPPDLNRTGFVEECQ----------GSSAVSYFWYRQTLNITA--DINDSGS 178

  Fly   243 VKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTP 307
            ::..|.:|:...:.:||..:.:|:.:.|||::.|||.||:||.|.|:||::||||.:|:.|..||
Human   179 IQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTP 243

  Fly   308 EWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIF 372
            ..|.|:|.:||:|||:||||||...||..:|.:|||...|:|.:||::.:.:|.:||..|...:|
Human   244 NMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVF 308

  Fly   373 SVLGYMA------------------------------------YVQKT----------------- 384
            ||||:.|                                    ::..|
Human   309 SVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLED 373

  Fly   385 SIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCD--EYPR 447
            .:|| ...||||.|:|:.|....|.|:..|:::||.||.||||.:.||.:||:||.|.|  ..||
Human   374 FLDK-SASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPR 437

  Fly   448 VIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRF 512
            .:.:.....::.|:.|:..... |:..|...|..|.| :.....:|.:.|:|..||.:.||:.||
Human   438 WVPKEALTGLVCLVCFLSATCF-TLQSGNYWLEIFDN-FAASPNLLMLAFLEVVGVVYVYGMKRF 500

  Fly   513 SSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSI-------MGYK------EML--GEEYYYP 562
            ..|:..|.|.:|..:||:.|..:||: |||||:..|       :.||      |:.  .:|..||
Human   501 CDDIAWMTGRRPSPYWRLTWRVVSPL-LLTIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYP 564

  Fly   563 DWSYQVGWAVTCSSVLCIPM 582
            .|:......::...||.:|:
Human   565 GWARAACVLLSLLPVLWVPV 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	202/583 (35%)
SLC6A18	NP_872438.2	SLC6sbd_B0AT3	17..591	CDD:212086	202/596 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	602..628

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810