DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and CG13795

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001285712.1	Gene:	CG13795 / 34049	FlyBaseID:	FBgn0031937	Length:	594	Species:	Drosophila melanogaster

Alignment Length:	596	Identity:	144/596 - (24%)
Similarity:	264/596 - (44%)	Gaps:	87/596 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVDL----GNVWRFPYICYQNGGGAFL 113
            |.:|.|              .|..|.:..:|:.|..|.|:.|    .:.|.|     .:.|...:
  Fly    13 PFSPDL--------------NRGKWDKPTDFMFACFGLALKLDVFVASFWMF-----FDMGILGI 58

  Fly   114 VPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWA 178
            :||.:::....:|:..:...:|||...|.:|.: |:.|..||:||....:.|.|.:||:......
  Fly    59 LPYFVYMSIYLVPIMVIHSFMGQFSSSGFISAF-RLSPFFKGMGYVSGFLTISMLIYYSIFAAVP 122

  Fly   179 VYYLFASFTSKLPWTSCD--NPWNTENCMQVTS-------ENFTELATS------PAKEFFER-- 226
            :.::..||...||| ||:  :.|:..:....:|       |:|:|...|      |:..:|:.
  Fly   123 LLFIINSFRPTLPW-SCEGLSSWHNGSATLSSSCNKTLILEDFSEYNRSHQLLHVPSVLYFQNHY 186

  Fly   227 ------KVLESYKGNGLD--FMGPVKPTLALCVFG-VFVLVYFSLWKGVRSA--GKVVWVTALAP 280
                  .|.:.||...|.  |:|         :|. ::|::.|..:|...:|  ||::....:..
  Fly   187 DSMQQDAVPDWYKDYELSWHFVG---------LFAIIWVVIAFIFYKFSETAKFGKLIRYMVIVT 242

  Fly   281 YVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAAS---QIFFSLGPGFGTLLALSSY 342
            .|:|::..||.:.||||..|:..|:||     |.|.:.:...|   .:..:.|.|:|:::.|||:
  Fly   243 LVLLLVCFVRFLFLPGALNGLHRYVTP-----KASDMAMGVVSTFIMVLHAFGAGWGSVITLSSF 302

  Fly   343 NKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVG-LEGPGLVFIVYPEAIA 406
            |.|..:....:.|.|........:.|.|.|.:..|  :.:.:.:|..| :....|:::....|::
  Fly   303 NGFKTDIMSYSWIISFGQIFIYIMFGMVSFMLEHY--FNELSDVDDNGHVLSHWLLYLSSASALS 365

  Fly   407 TMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPT 471
            ||:....|:.|::.||:...|......:..::.:|.||: .|:..|::.....|:..|.||:...
  Fly   366 TMAWPNLWTFIYYSMLLIAALIVMTTQIFTVLQSLFDEF-EVLRVRKQEVTFGLIGGIALCSFYF 429

  Fly   472 MTYGGVVLVNFLN---VYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRI-CW 532
            .|..|::..:.|.   ::...|..|.::.|    |.|.||.:||..|:|.||| :|...|:: ..
  Fly   430 CTNHGIIFFSALGLDAIFSHSLLHLLLLLV----VLWIYGRERFQRDIEFMLG-QPFASWKVFIL 489

  Fly   533 TYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCR 597
            .:|:|:.|:   |..:.|....:.|..|.....:.:...:....:|.||.|..| :.:.|.|...
  Fly   490 RFIAPIILV---ICLLAGIALSISEHSYSTTVVFVMSIVLVVLPILAIPGYGFY-YLYQSTGTFC 550

  Fly   598 QRLQESFQPED 608
            :|.:.:.:|.|
  Fly   551 ERFKRTCRPTD 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	139/572 (24%)
CG13795	NP_001285712.1	SLC5-6-like_sbd	27..505	CDD:271356	126/509 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840