DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and CG13794

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_609137.2	Gene:	CG13794 / 34048	FlyBaseID:	FBgn0031936	Length:	595	Species:	Drosophila melanogaster

Alignment Length:	602	Identity:	138/602 - (22%)
Similarity:	266/602 - (44%)	Gaps:	95/602 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYC 117
            |.:|.|              .|..|.:..:::.|..|.|:.| :::...|..:.:.|...::||.
  Fly    13 PFSPDL--------------KRGKWDKPTDYIFACFGLALKL-DIFVASYWFFFDMGIFGMLPYL 62

  Fly   118 LFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYL 182
            ::::...:|:..:...:|||...|.:|.: |:.|..||:||....:.|.|.:||:......:.::
  Fly    63 VYMVIYLVPIMVIHSFMGQFSSSGFISAF-RLSPFFKGMGYVSVFLTISMLIYYSIFAAVPLLFM 126

  Fly   183 FASFTSKLPWTSCD--NPWNTEN------CMQVTSENFTELATSPAK---------------EFF 224
            ..||...||| ||:  ..|..|:      |....||:.|:.:.:...               :.|
  Fly   127 INSFRPTLPW-SCEGFKSWYNESDGKMTTCNMTISEDLTDNSDNNTDFHRPHFHVPSVLYFLKHF 190

  Fly   225 ERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVY----FSLWKGVRSA--GKVVWVTALAPYVV 283
            |....|:|.....|:      .|:.....:||||:    |..:|...:|  ||.:....:...::
  Fly   191 ESVQEENYSDLRQDY------DLSWRFVSLFVLVWAMVAFIFYKFSETAMFGKFIRYMVIGTLIL 249

  Fly   284 LIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAAS---QIFFSLGPGFGTLLALSSYNKF 345
            |::...|.:.||||..|::.|:||     ...::.:...|   .:..:.|.|:|:::||||:|.|
  Fly   250 LLVCFGRFLFLPGALLGLRKYVTP-----SPDEIAMGIGSTFVMVLHAFGAGWGSVIALSSFNGF 309

  Fly   346 NNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGP--------GLVFIVYP 402
            ..:       ..|.:.:.|| ....||::.|.::|:.....:: |:||.        ..:::...
  Fly   310 KTD-------IMSYSWIISF-GQIFIFTMFGLVSYMLDHYYNE-GIEGSFDKQVLTHWALYLSSA 365

  Fly   403 EAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLC 467
            .|::::.....|:.|::.||:...|......:..::.:|.||: .|:..|::.....|:..|.:|
  Fly   366 TALSSLGWPNLWTFIYYTMLLMAALIVITTQIFTVLQSLFDEF-EVLRVRKQEVTFGLIGGIAVC 429

  Fly   468 ALPTMTYGGVVLVNFL---NVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWR 529
            :....|..|:...:.|   .::...|..|.::.|    |.|.||.:||..|:|.||| :|...|:
  Fly   430 SFYFCTNHGITFFSALALDAIFSHSLLHLLLLLV----VLWIYGRERFQRDIEFMLG-QPFASWK 489

  Fly   530 I-CWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAV--TCSSVLCIPMYIIYKFFFA 591
            : ...:|:|:.|:...:..|:    :...|:.|.. :..:|.::  ....:|.||.|.|| :.:.
  Fly   490 VYILRFIAPIILIICLVVGIL----VCYMEHIYSS-AIVLGMSIILVILPILAIPGYGIY-YIYR 548

  Fly   592 SKGGCRQRLQESFQPED 608
            |.|...:|.:.:.:|.|
  Fly   549 STGSFCERFKRTCRPTD 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	133/578 (23%)
CG13794	NP_609137.2	SLC5-6-like_sbd	27..509	CDD:271356	118/510 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440804
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840