DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and CG10804

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001138150.1	Gene:	CG10804 / 31317	FlyBaseID:	FBgn0029663	Length:	726	Species:	Drosophila melanogaster

Alignment Length:	717	Identity:	239/717 - (33%)
Similarity:	351/717 - (48%)	Gaps:	129/717 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GRSNPAPWSD--DKESPNNEDDSNEDDGDHTTPAKV-TDPLAPKLANNERILVVSVTERTRETWG 78
            |.:|....||  |:.|...:|.........|:.||. ...:|...|:.:.|:........||:|.
  Fly    58 GATNQGFMSDAFDESSELEQDPPPFGSEASTSKAKAELVAIATASADQQDIVEGEKEGEERESWD 122

  Fly    79 QKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCL 143
            .|..||||.||:||.|||||||||:..:||||||||||.:.|...|:|:||:|||:||..|.|.:
  Fly   123 SKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIGQRLRKGAI 187

  Fly   144 SIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQVT 208
            .:|.::.|.|.|:|.:..::...:.:||||||.|.:.||..||.|.|||..|...         .
  Fly   188 GVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADCPTR---------L 243

  Fly   209 SENFTE------LATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVR 267
            .:|||.      :|:||.:.::.|..|:.  ...:|........:|:.:...:.|||..:.:|:.
  Fly   244 YKNFTYDHEPECVASSPTQFYWYRTTLQC--SESVDMPENFNYHMAIALIVSWFLVYICMVQGIT 306

  Fly   268 SAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPG 332
            |:||:|::||:.|||||||...||::|.||.:|:.:..||.|..|.:..||::|.:|||||||..
  Fly   307 SSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLA 371

  Fly   333 FGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYV--QKTSIDKVGL---- 391
            ||.|:|.||||..||||||||::.|..||.||..||.|:|||:|:.|..  .:.:.::.||
  Fly   372 FGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQN 436

  Fly   392 ------------------EGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMI 438
                              .|.||.||::.|||....|:..|:::|||||.|||:||.||.||.::
  Fly   437 KTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVV 501

  Fly   439 TALCD---------EYPRVIGRRRELFVLLLLAFIFLCALPTMTY---GGVVLVNFLNVYGPGLA 491
            |:|.|         ||  ::|           |..|.|...:|.:   .|..:...::.:.....
  Fly   502 TSLVDMKLFPNLPKEY--IVG-----------ALCFSCCTISMCFANGAGSYIFQLMDSFAGNFP 553

  Fly   492 ILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEMLG 556
            :|.:...|...:.:.|||.|||.|:|.|.||:|..:|..||.|:||..::||.:.|   :.::|.
  Fly   554 LLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTILLAS---FYQLLT 615

  Fly   557 EEYYYPDWSYQVG------WAVTC---------SSVLCIPMYIIYKFFFASKGGCRQRLQESFQP 606
            |...||.|....|      |...|         ||:|.||:..:.:.       |..::.|...|
  Fly   616 EGSSYPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIPIVAVLRL-------CGIKVVEDSDP 673

  Fly   607 E-------DNCGSVVPGQQGTSVXHDHAQVHVNIRTSCTSIKIYNLNCSSNSNSLSPTTSGAEGR 664
            .       .....:||        |:..::.       .||..:|::             |.||.
  Fly   674 AWFPEAELREVHGIVP--------HEPTELE-------RSIFCFNMD-------------GTEGM 710

  Fly   665 SC 666
            .|
  Fly   711 CC 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	215/589 (37%)
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	211/567 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910