DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and Slc6a14

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_038955501.1	Gene:	Slc6a14 / 298340	RGDID:	1561810	Length:	646	Species:	Rattus norvegicus

Alignment Length:	613	Identity:	252/613 - (41%)
Similarity:	367/613 - (59%)	Gaps:	48/613 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 HTTPAKVTDPLAPKLANNERILVVSVTE-RTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQN 107
            |....|||       |::|...|....| :.|..|.:|:::||:::|:||.|||||||||:.|.|
  Rat    18 HRFCQKVT-------ASSENFHVGENDENQERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTN 75

  Fly   108 GGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYN 172
            ||||||:||.:.|...|||||::|.:||||...|.:|:| ||.|..:|||..:.||.|::.:|||
  Rat    76 GGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVW-RILPLFQGVGITMVLISIFVTIYYN 139

  Fly   173 TIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQ-----------------------VTSENFTE 214
            .||.:::|||||||.|.|||.:|.:.|..:||.:                       |.|.|||.
  Rat   140 VIIAYSLYYLFASFQSVLPWANCSSSWADDNCSRQPIVTGCRVSTDTGGDMFMNISWVNSNNFTC 204

  Fly   215 LATS--------PAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGK 271
            |..|        |:::::::..|.  :.:|:|..|.:...||||:...:::|..:|:||::|:||
  Rat   205 LNGSEVFRPGQLPSEQYWDKVTLR--RSSGMDETGVIVWYLALCLLLAWIIVGAALFKGIKSSGK 267

  Fly   272 VVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPE--WHKLKNSKVWIDAASQIFFSLGPGFG 334
            ||:.|||.|||||:|||:||.:|.||.:||.||:..:  :.||:.::||.|||:|||:||...:|
  Rat   268 VVYFTALFPYVVLLILLIRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWG 332

  Fly   335 TLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFI 399
            .|:|||||||||||||.||:|....|||||..|||.|||:||:||::....:.:|...|..|.||
  Rat   333 GLVALSSYNKFNNNCYSDAIIVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFI 397

  Fly   400 VYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFI 464
            .||||:|.:.|..||||:||.||:||||||.|..:|.:.|.:.|.:|:.:.|.|....|.....:
  Rat   398 AYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKAMKRMRVPITLGCCLIL 462

  Fly   465 FLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLF-- 527
            ||..|..:|..|:..|:.::.:..|..||....:|.||:.|.||.:||..|:|.|:|:|..||
  Rat   463 FLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWLFWL 527

  Fly   528 -WRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFA 591
             ||.||..|:|:.|..|.::|::.:......:..||||...:||.:....::.||:..|.|...|
  Rat   528 WWRACWFVITPILLSAILVWSLVKFHRPNYADIPYPDWGVALGWCMIIFCIIWIPIMAIIKIVRA 592

  Fly   592 SKGGCRQRLQESFQPEDNCGSVVPGQQG 619
             :|...||:.:..:|..|.|..:...:|
  Rat   593 -EGNILQRIIKCCRPASNWGPYLEKHRG 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	240/568 (42%)
Slc6a14	XP_038955501.1	SLC6sbd_ATB0	42..645	CDD:271391	244/582 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820