Protein Alignment SerT and Slc6a18

DIOPT Version :9

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_058859.2
• Gene: Slc6a18 / 29323
• RGDID: 69352
• Length: 615
• Species: Rattus norvegicus
• Alignment Length: 618
• Identity: 214/618 - (34%)
• Similarity: 313/618 - (50%)
• Gaps: 94/618 - (15%)

  Fly    71 ERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALG 135
            |..|..|..|.::||:.|||||.|||:|||||:|:.:||||||:||.:.|:|.|:||||:|||:|
  Rat    14 EDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCHTHGGGAFLIPYFIALVFEGIPLFYIELAIG 78

  Fly   136 QFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWN 200
            |..|.|.:.:||.|.|.|.|||.....:...:.:|||||:.|.:::...||...|||::|....|
  Rat    79 QRLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTILLWVLWFFLNSFQHPLPWSTCPLDLN 143

  Fly   201 TENCMQVTSENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKG 265
            ....:|....:.|      ...|:.|:.|..  .:.:...|.::..|.||:...:..||..:.:|
  Rat   144 RTGFVQECQSSGT------VSYFWYRQTLNI--TSDISNTGTIQWKLFLCLVACWTTVYLCVIRG 200

  Fly   266 VRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLG 330
            :.|.|||::.|||.||:||.|.|:||::||||.||:.|..||....|:|.:||:|||:||||||.
  Rat   201 IESTGKVIYFTALFPYLVLTIFLIRGLTLPGATEGLTYLFTPNMKILQNPRVWLDAATQIFFSLS 265

  Fly   331 PGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMA---------------- 379
            ..||..:|.:|||:..|||.:||:..:.:|.:||..|...|||::|:.|
  Rat   266 LAFGGHIAFASYNQPRNNCEKDAVTIALVNSMTSLYASITIFSIMGFKASNDYGRCLDRNILSLI 330

  Fly   380 --------------------YVQKTSIDKVG--------LE--------GPGLVFIVYPEAIATM 408
                                |:..|..::|.        ||        ||||.|||:.||:..|
  Rat   331 NEFDFPELSISRDEYPSVLMYLNATQPERVARLPLKTCHLEDFLDKSASGPGLAFIVFTEAVLHM 395

  Fly   409 SGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMT 473
            .|:..||::||.||.||||.|.||.:|.:||.|.|......|..:|....::....||.|:....
  Rat   396 PGASVWSVLFFGMLFTLGLSSMFGNMEGVITPLFDMGILPKGVPKETMTGVVCFICFLSAICFTL 460

  Fly   474 YGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPV 538
            ..|...:...:.:...|.::...|:|..||...||:.||..|:|.|.|.:|.|:|::.|..:||:
  Rat   461 QSGSYWLEIFDSFAASLNLIIFAFMEVVGVIHVYGIKRFCDDIEWMTGRRPSLYWQVTWRVVSPM 525

  Fly   539 FLLTIFIFSIM-------GYKEM--------LGEEYYYPDWSYQVGWAVTCSSV-----LCIPMY 583
            .|..||:..|:       .||..        ..||..||.|.     .|||..:     |.:|..
  Rat   526 LLFGIFLSYIVLLAQSSPSYKAWNPQYEHFPSREEKLYPGWV-----QVTCVLLSFLPSLWVPGI 585

  Fly   584 IIYKFFFASKGGCRQR-----LQESFQPEDNCG 611
            .:.:..|.    .|||     |:.:.:|:::.|
  Rat   586 ALAQLLFQ----YRQRWKNTHLESALKPQESRG 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	211/609 (35%)
Slc6a18	NP_058859.2	SLC6sbd_B0AT3	16..591	CDD:212086	206/587 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810