DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and Slc6a4

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_037166.2	Gene:	Slc6a4 / 25553	RGDID:	3714	Length:	630	Species:	Rattus norvegicus

Alignment Length:	612	Identity:	322/612 - (52%)
Similarity:	427/612 - (69%)	Gaps:	25/612 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GAAATTGRSNPAPWSDDKES-PNNEDDSNEDDGDHTTPAKVTDPLAPKLANNERILVVSVTERTR 74
            |...|..|:.|:..|:...: |:.   |..|:..|:.||..|            .||..:.:..|
  Rat    30 GVPTTADRAEPSQISNGYSAVPST---SAGDEASHSIPAATT------------TLVAEIRQGER 79

  Fly    75 ETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHR 139
            ||||:|.:|||:|||:||||||:||||||||||||||||:||.:..||||:|||||||||||:||
  Rat    80 ETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHR 144

  Fly   140 CGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENC 204
            .||:|||::|||..||:|||||:|..|:..||||||.||:|||.:|.|.:||||||.|.|||.||
  Rat   145 NGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNC 209

  Fly   205 MQVTSEN---FTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGV 266
            ....:::   :|..:||||:||:.|.||:.::..||..:|.:...|.||:..:|.::|||:||||
  Rat   210 TNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGV 274

  Fly   267 RSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGP 331
            :::||||||||..||:||.:|||||.:||||..|:.:||.|.|.||..:.||:|||:||||||||
  Rat   275 KTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGP 339

  Fly   332 GFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLE-GPG 395
            |||.|||.:||||||||||:|||:||.:||:|||::|||||:||||||.::...:.:|..: ||.
  Rat   340 GFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPS 404

  Fly   396 LVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLL 460
            |:||.|.||||.|..|.|::||||||||||||||||.|||.:|||:.||:|.:..:|||.|||::
  Rat   405 LLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIV 469

  Fly   461 LAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPG 525
            :....|.:|.|:|.||..:|..|..|..|.|:|.|..:||..|.||||:.:|.|||::|||..||
  Rat   470 VITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPG 534

  Fly   526 LFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFF 590
            .||||||..|||:|||.|....:|...::...:|.||.||..:|:.:..|||:|||.||||: ..
  Rat   535 WFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYR-LI 598

  Fly   591 ASKGGCRQRLQESFQPED----NCGSV 613
            ::.|..::|:.:|..||.    .||.:
  Rat   599 STPGTLKERIIKSITPETPTEIPCGDI 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	304/536 (57%)
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..60		8/32 (25%)
		5HT_transport_N	24..64	CDD:397524	9/36 (25%)
		SLC6sbd_SERT	79..615	CDD:271399	304/536 (57%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		1/7 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	650	1.000	Domainoid score	I150
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	664	1.000	Inparanoid score	I723
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		oto96241
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.980