Protein Alignment SerT and Slc6a6

DIOPT Version :10

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_033346.2
• Gene: Slc6a6 / 21366
• MGIID: 98488
• Length: 621
• Species: Mus musculus
• Alignment Length: 635
• Identity: 253/635 - (39%)
• Similarity: 365/635 - (57%)
• Gaps: 61/635 - (9%)

  Fly    28 KESPNNEDDSN-EDDGDHTTPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFA 91
            |.||.....:. ||:.|...|                         .||.|..|.:|:|:|.|..
Mouse    19 KPSPGKSPGTRPEDEADGKPP-------------------------QREKWSSKIDFVLSVAGGF 58

  Fly    92 VDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGV 156
            |.|||||||||:||:|||||||:||.:||...|||:|::|:.:||:...|.::.|::|||...|:
Mouse    59 VGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGI 123

  Fly   157 GYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQ------------VTS 209
            |||..:|...:.:||..|:.||.||||.||...|||..|::.|||..||:            :::
Mouse   124 GYASIVIVSLLNVYYIVILAWATYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLST 188

  Fly   210 ENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVW 274
            .||    |||..||:||.||.  ..:|:|..|.:|..||||:..|:::.:|.:||||||.||||:
Mouse   189 ANF----TSPVIEFWERNVLS--LSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVY 247

  Fly   275 VTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLAL 339
            .||..|:.:|::|||||::||||.||||:||.|:..:|.:.:|||||.:|||||.....|.:.:|
Mouse   248 FTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPDISRLGDPQVWIDAGTQIFFSYAICLGAMTSL 312

  Fly   340 SSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEA 404
            .||||:..|.|||.::...:|..|||::||.|||:||:||..|...|..|...||||.||.||:|
Mouse   313 GSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKA 377

  Fly   405 IATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVI--GRRRELFVLLLLAFIFLC 467
            :..|....||||:||:||:.|||||.|..:|..||:|.|.||..:  |.|||:|:.:|.:..:|.
Mouse   378 VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAILCSISYLL 442

  Fly   468 ALPTMTYGGVVLVNFLNVY-GPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRIC 531
            .|..:|.||:.:....:.| ..|:.:|:|.|.|...:.|.||.|.....:|.|:|.:||.:.:..
Mouse   443 GLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYS 507

  Fly   532 WTYISPVFLLTIFIFSIMGYKEM-LGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGG 595
            |..|:|...:..|:||::.|..: ..:.|.||||:..:||.:..||:||||:.|:. ....::|.
Mouse   508 WAVITPALCVGCFVFSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMLCIPLVIVI-LLCRTEGP 571

  Fly   596 CRQRLQESFQP-EDNCGSVVPGQQGTSVXHDHAQV---------HVNIRT 635
            .|.|::....| |.|..:|  .::|.:. |....:         ||.:.|
Mouse   572 LRVRIKYLITPREPNRWAV--EREGATPFHSRVTLMNGALMKPSHVIVET 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	238/549 (43%)
Slc6a6	NP_033346.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		7/47 (15%)
		SLC5-6-like_sbd	41..582	CDD:444915	237/547 (43%)