DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and Slc6a6

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_030111163.1	Gene:	Slc6a6 / 21366	MGIID:	98488	Length:	631	Species:	Mus musculus

Alignment Length:	635	Identity:	253/635 - (39%)
Similarity:	365/635 - (57%)	Gaps:	61/635 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KESPNNEDDSN-EDDGDHTTPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFA 91
            |.||.....:. ||:.|...|                         .||.|..|.:|:|:|.|..
Mouse    29 KPSPGKSPGTRPEDEADGKPP-------------------------QREKWSSKIDFVLSVAGGF 68

  Fly    92 VDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGV 156
            |.|||||||||:||:|||||||:||.:||...|||:|::|:.:||:...|.::.|::|||...|:
Mouse    69 VGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGI 133

  Fly   157 GYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQ------------VTS 209
            |||..:|...:.:||..|:.||.||||.||...|||..|::.|||..||:            :::
Mouse   134 GYASIVIVSLLNVYYIVILAWATYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLST 198

  Fly   210 ENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVW 274
            .||    |||..||:||.||.  ..:|:|..|.:|..||||:..|:::.:|.:||||||.||||:
Mouse   199 ANF----TSPVIEFWERNVLS--LSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVY 257

  Fly   275 VTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLAL 339
            .||..|:.:|::|||||::||||.||||:||.|:..:|.:.:|||||.:|||||.....|.:.:|
Mouse   258 FTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPDISRLGDPQVWIDAGTQIFFSYAICLGAMTSL 322

  Fly   340 SSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEA 404
            .||||:..|.|||.::...:|..|||::||.|||:||:||..|...|..|...||||.||.||:|
Mouse   323 GSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKA 387

  Fly   405 IATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVI--GRRRELFVLLLLAFIFLC 467
            :..|....||||:||:||:.|||||.|..:|..||:|.|.||..:  |.|||:|:.:|.:..:|.
Mouse   388 VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAILCSISYLL 452

  Fly   468 ALPTMTYGGVVLVNFLNVY-GPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRIC 531
            .|..:|.||:.:....:.| ..|:.:|:|.|.|...:.|.||.|.....:|.|:|.:||.:.:..
Mouse   453 GLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYS 517

  Fly   532 WTYISPVFLLTIFIFSIMGYKEM-LGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGG 595
            |..|:|...:..|:||::.|..: ..:.|.||||:..:||.:..||:||||:.|:. ....::|.
Mouse   518 WAVITPALCVGCFVFSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMLCIPLVIVI-LLCRTEGP 581

  Fly   596 CRQRLQESFQP-EDNCGSVVPGQQGTSVXHDHAQV---------HVNIRT 635
            .|.|::....| |.|..:|  .::|.:..|....:         ||.:.|
Mouse   582 LRVRIKYLITPREPNRWAV--EREGATPFHSRVTLMNGALMKPSHVIVET 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	238/549 (43%)
Slc6a6	XP_030111163.1	SLC5-6-like_sbd	51..592	CDD:382020	237/547 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830