DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and Slc6a13

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001366036.1	Gene:	Slc6a13 / 14412	MGIID:	95629	Length:	602	Species:	Mus musculus

Alignment Length:	584	Identity:	252/584 - (43%)
Similarity:	365/584 - (62%)	Gaps:	25/584 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EDDGDHTTPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYI 103
            |:....||....|.|:.|.:   |::......|  ||.|..|.||:|:|.|..:.|||||||||:
Mouse     2 ENRASGTTSNGETKPVCPAM---EKVEEDGTLE--REHWNNKMEFVLSVAGEIIGLGNVWRFPYL 61

  Fly   104 CYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMG 168
            ||:||||||.:||.:||...|:|:|::|.||||:...|.::.|:||||..:|:|||..:|...:.
Mouse    62 CYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQMIVSLLN 126

  Fly   169 MYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENC---------MQVTSENFTELATSPAKEFF 224
            :||..::.||::|||:|||:.|||.||.:.||||||         |.|||||    ||||..||:
Mouse   127 VYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSEN----ATSPVIEFW 187

  Fly   225 ERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLV 289
            ||:||:  ..:|:..:|.::..|.||:...:::.||.:||||:|.||||:.||..||::|::||:
Mouse   188 ERRVLK--LSDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLI 250

  Fly   290 RGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDAL 354
            |||:||||.:||::||.|...:|.:.:||:||.:|||||.....|.|.||.||||::||||||.:
Mouse   251 RGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCI 315

  Fly   355 ITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFF 419
            ....:|..|||:|||.|||:||:|:..|...|.:|...||||.||.||.|:..:..|..|:..||
Mouse   316 ALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFF 380

  Fly   420 LMLITLGLDSTFGGLEAMITALCDEYPRVIGR--RRELFVLLLLAFIFLCALPTMTYGGVVLVNF 482
            .|::.|||||.|..:|:::|||.|.||||..:  |||:.:|::....|...|..:|.||:.:...
Mouse   381 FMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREVLILIVSVISFFIGLIMLTEGGMYVFQL 445

  Fly   483 LNVY-GPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIF 546
            .:.| ..|:.:|||...|:..|.|.||..||..::|.|:|.||....:.||.:.:|...|..|:|
Mouse   446 FDYYAASGMCLLFVAIFESLCVAWVYGAGRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLF 510

  Fly   547 SIMGYKEM-LGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQESFQPEDN 609
            |::.|..: ..::|.||.|...:||.:..||::|||.:.||| ....||..|:||::...|.::
Mouse   511 SLIKYTPLTYNKKYTYPWWGDALGWLLALSSMICIPAWSIYK-LRTLKGPLRERLRQLVCPAED 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	243/545 (45%)
Slc6a13	NP_001366036.1	SLC5-6-like_sbd	32..575	CDD:382020	244/549 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830