DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerT and Slc6a7

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_446448.2	Gene:	Slc6a7 / 117100	RGDID:	620928	Length:	637	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	243/547 - (44%)
Similarity:	341/547 - (62%)	Gaps:	12/547 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFH 138
            |..|..|.:|||:.||:.|.|||||||||..|.||||||||||.|.|...|:|||::||:||||.
  Rat    37 RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFS 101

  Fly   139 RCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTEN 203
            ..|.|::|| |.|..||.|.|:.||...:.:|||.||.:.::|||||.||.|||..|.|.||||.
  Rat   102 SLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSNLPWEHCGNWWNTER 165

  Fly   204 CMQ---------VTSENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVY 259
            |::         ....|.:. ..||::|::.|.||......|:...|.::..|.||:...:|:|:
  Rat   166 CLEHRGPKDGNGALPLNLSS-TVSPSEEYWSRYVLHIQGSQGIGRPGEIRWNLCLCLLLAWVIVF 229

  Fly   260 FSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQ 324
            ..:.|||:|:||||:.||..||::|::||||||:||||.:||::||||::|.|.:|||||:||.|
  Rat   230 LCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQ 294

  Fly   325 IFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKV 389
            ||:|||.|||.||..:|||.|:.|.|||..|.:..|.:||.||||.||||||||:......:|:|
  Rat   295 IFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQV 359

  Fly   390 GLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRE 454
            ...||||.|:|||:|:..:..|.|||.:||.||:||||||.|..||.::||:.||:|..:..::.
  Rat   360 AKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKA 424

  Fly   455 LFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQM 519
            :|..|:...::|..|...|.||:..:..|:.|.....::.||......|...||:.||..|:..|
  Rat   425 VFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMM 489

  Fly   520 LGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYI 584
            ||.||||::|.||.::||..||.:.::||:.|:......|.:|.|:..:|..:...|.|.||..:
  Rat   490 LGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYRFPAWAELLGILMGLLSCLMIPAGM 554

  Fly   585 IYKFFFASKGGCRQRLQESFQPEDNCG 611
            :.. ....:|...:|||::.:|..:.|
  Rat   555 LVA-VLREEGSLWERLQQASRPAIDWG 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	241/541 (45%)
Slc6a7	NP_446448.2	SLC5-6-like_sbd	37..581	CDD:382020	243/547 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820