DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerT and Slc6a9

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_006238687.1	Gene:	Slc6a9 / 116509	RGDID:	621243	Length:	638	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	242/567 - (42%)
Similarity:	348/567 - (61%)	Gaps:	38/567 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 TRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQF 137
            ||..||.:.||:|..:|:||.|||||||||:||:||||||:.||.:.|:|.|:|||:|||:.|||
  Rat    31 TRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQF 95

  Fly   138 HRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTE 202
            ...|||.:| ||.|..|||||.:.::..|:|:|||.:|..|.||.|:|.|..|||..|:|||||.
  Rat    96 ASQGCLGVW-RISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTP 159

  Fly   203 NCMQVTSE--------------------NFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTL 247
            :|..|...                    |:|...|||::|::...||:.....| || |.|:..|
  Rat   160 DCAGVLDASNLTNGSRPTALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIG-DF-GEVRLPL 222

  Fly   248 ALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKL 312
            ..|:...:|:|:..|.:||:|:||||:.||..|||||.||.||||:|.||..||.|||||:|.|:
  Rat   223 LGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPKWDKI 287

  Fly   313 KNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGY 377
            ..:|||.|||||||:|||..:|.|:.::|||||:||||||::|.|..||.||..|||||||:||:
  Rat   288 LEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF 352

  Fly   378 MAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALC 442
            ||......:.:|...||||.|:.||||:..:..|..||::||.|||.|||.:.|..||.::||:.
  Rat   353 MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIV 417

  Fly   443 DEYPRVIGRRRELFVLLLLAFI-FLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWF 506
            ||.......:::.:|.|.:|.. ||..:|..:..|:..:..::.|....:::.:..:....:.:.
  Rat   418 DEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYI 482

  Fly   507 YGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWA 571
            ||...:..|::.|||..|.||::|||.::||..:..|.||:::.|:.:....|.||.|:..:|:.
  Rat   483 YGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFL 547

  Fly   572 VTCSSVLCIPMYIIYKFFFASKGGCR-------QRLQESFQPEDNCG 611
            :..|||:|||:|.:::.       ||       |||:.:.:|..:.|
  Rat   548 MALSSVICIPLYALFQL-------CRTDGDTLLQRLKNATKPSRDWG 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	239/560 (43%)
Slc6a9	XP_006238687.1	SLC6sbd_GlyT1	16..599	CDD:212067	242/567 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820