Protein Alignment SerT and Slc6a5

DIOPT Version :9

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: XP_006540608.1
• Gene: Slc6a5 / 104245
• MGIID: 105090
• Length: 831
• Species: Mus musculus
• Alignment Length: 643
• Identity: 262/643 - (40%)
• Similarity: 385/643 - (59%)
• Gaps: 61/643 - (9%)

  Fly    34 EDDSNEDDGDHT-----TPA------------KVTDPLAPKLANNERILVVSVTE-----RTRET 76
            |:|:|...|..|     |||            ..||.:|..|..:.....:...|     :.|..
Mouse   163 EEDANVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARGN 227

  Fly    77 WGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCG 141
            |..|.:|:|:::|:||.|||||||||:.:||||||||:||.:.|...|||:|::|::||||...|
Mouse   228 WSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQG 292

  Fly   142 CLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCM- 205
            .:|:||.| |||:|.|.|:.:|.:.:.:|||.||.:.::||||||.|.|||.||:|||||..|.
Mouse   293 PVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKD 356

  Fly   206 ------------------------------QVTSENFT----ELATSPAKEFFERKVLESYKGNG 236
                                          .:|..|||    :...|.::|:|:..||:.  ..|
Mouse   357 KTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQTNKTFVSGSEEYFKYFVLKI--SAG 419

  Fly   237 LDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGI 301
            :::.|.::..||.|:|..:|:||.||.||::|:||||:.||..|||||:|||:|||:||||..||
Mouse   420 IEYPGEIRWPLAFCLFLAWVIVYASLAKGIKSSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGI 484

  Fly   302 KYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFL 366
            .|::||:|.||.::.||.|||:||||||...:|.|:.|||||||:||||||.||.:..|..||..
Mouse   485 WYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIF 549

  Fly   367 AGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTF 431
            ||||||||:|:||..:|.:|:.|..:|||:.|:|||||:..:..|.||:|||||||:|||||:.|
Mouse   550 AGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMF 614

  Fly   432 GGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVV 496
            ..:|.::|::.||:|:.:...:.:|.|......|:...|.:|.||:.:...::.|....|::.:.
Mouse   615 ATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIA 679

  Fly   497 FVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYY 561
            ..|..|:.:.||:.||..|:|.|:|.||.:||::||.:::|..|..|..||...::.|....|.|
Mouse   680 IFELVGISYVYGLQRFCEDIEMMIGFKPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRY 744

  Fly   562 PDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQESFQPEDNCGSVVPGQQG 619
            |:||..:||.:...||:.||:..:.|.:.| .|...:||:....|:.:.|..:...:|
Mouse   745 PNWSMVLGWLMLACSVIWIPIMFVIKMYLA-PGRFIERLKLVCSPQPDWGPFLAQHRG 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	246/567 (43%)
Slc6a5	XP_006540608.1	SLC6sbd_GlyT2	225..821	CDD:271389	249/581 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920