Protein Alignment SerT and Slc6a15

DIOPT Version :10

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_780537.1
• Gene: Slc6a15 / 103098
• MGIID: 2143484
• Length: 729
• Species: Mus musculus
• Alignment Length: 661
• Identity: 213/661 - (32%)
• Similarity: 333/661 - (50%)
• Gaps: 126/661 - (19%)

  Fly    31 PNNEDDSNED-DGDHTTPAKVTDPLAPKLANNERI--------LVVSVTER-------------T 73
            |.|......| |.|      |.:.:...|:|.:.:        |:|.|.|.             .
Mouse     2 PKNSKVVKRDLDDD------VIESVKDLLSNEDSVEEVSKKSELIVDVQEEKDTDAEDGSEADDE 60

  Fly    74 RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFH 138
            |..|..|.:::||.:||:|.|||||||||:|.:|||||:|:||.:.|:..|:|||::||::||..
Mouse    61 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLLVIGIPLFFLELSVGQRI 125

  Fly   139 RCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTEN 203
            |.|.:.:|..|.|.|.|:|:|.|::..::.:|||.||||.::|...||...|||..|....|..:
Mouse   126 RRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWTLFYFSQSFQQPLPWDQCPLVKNASH 190

  Fly   204 ------CMQVTSENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSL 262
                  |.|.::..:          ::.|:.|:.  .:.:...|.:...:.:|:...:|:|..::
Mouse   191 TYVEPECEQSSATTY----------YWYREALDI--TSSISDSGGLNWKMTVCLLVAWVMVCLAM 243

  Fly   263 WKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFF 327
            .||::|:||:::.::|.||||||..|:|.:.|.|:.:||::..||:...:...|||.:||:|:||
Mouse   244 IKGIQSSGKIMYFSSLFPYVVLICFLIRSLLLNGSIDGIRHMFTPKLEMMLEPKVWREAATQVFF 308

  Fly   328 SLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMA------------- 379
            :||.|||.::|.|||||.:|||:.||::.|.||..||.||..|:|:|||:.|
Mouse   309 ALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANIVNEKCISQNSE 373

  Fly   380 -----------------------------------YVQKTSIDKV----------------GLEG 393
                                               .:||...::.                .::|
Mouse   374 MILKLLKMGNISWDVIPHHINLSAVTVEDYRLVYDIIQKVKEEEFAVLHLNACQIEDELNKAVQG 438

  Fly   394 PGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVL 458
            .||.||.:.||:.....|.|||::||||||.|||.|.||.:|.:||.:.|.: :|   |:|:..:
Mouse   439 TGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMFGTIEGIITPIVDTF-KV---RKEILTV 499

  Fly   459 LLLAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSK 523
            :.....|...|..:...|...|...:.|...|.:|.||.:|...|.:.||:|:|..|:..|||..
Mouse   500 ICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVSFVYGIDKFIEDLTDMLGFA 564

  Fly   524 PGLFWRICWTYISPVFLLTIFIFSIM-------GY----KEMLGEEYY-YPDWSYQVGWAVTCSS 576
            |..::...|.||||:.|||:.|.||:       ||    ||...||:. ||.|...|.:::...:
Mouse   565 PSKYYYYMWKYISPLMLLTLLIASIVNMGLSPPGYNAWIKEKASEEFLSYPMWGMVVCFSLMVLA 629

  Fly   577 VLCIPMYIIYK 587
            :|.:|:..|.:
Mouse   630 ILPVPVVFIIR 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	201/596 (34%)
Slc6a15	NP_780537.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..61		2/18 (11%)
		SLC6sbd_SBAT1	61..640	CDD:212091	201/594 (34%)