DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and Slc6a8

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_598748.1	Gene:	Slc6a8 / 102857	MGIID:	2147834	Length:	640	Species:	Mus musculus

Alignment Length:	603	Identity:	263/603 - (43%)
Similarity:	362/603 - (60%)	Gaps:	38/603 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DDKESPNNEDDSNEDDGDHTTPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGF 90
            |:|:.|...      .|....|||...| |...|...|:.|     ..||||.::.:|:::.:||
Mouse    16 DEKKGPLIV------SGPDGAPAKGDGP-AGLGAPGGRLAV-----PPRETWTRQMDFIMSCVGF 68

  Fly    91 AVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKG 155
            ||.|||||||||:||:||||.||:||.|..:.||:|:|::|::||||.:.|.:::| .|||..||
Mouse    69 AVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVW-NICPLFKG 132

  Fly   156 VGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQV---------TSEN 211
            :|||..:|..|...||..::.|..|||..|||:.|||.:|.:.|||.:|:::         :..|
Mouse   133 LGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLAN 197

  Fly   212 FT--ELA--TSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKV 272
            .|  :||  .||..||:|.|||.  ...||:..|.:...:.||:...:|||||.:||||:|.||:
Mouse   198 LTCDQLADRRSPVIEFWENKVLR--LSTGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKI 260

  Fly   273 VWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLL 337
            |:.||..|||||::||||||.||||.:||.|||.|:|.||.:.:|||||.:|||||...|.|.|.
Mouse   261 VYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALT 325

  Fly   338 ALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYP 402
            ||.|||:||||||:||:|.:.||..|||.||||:||:||:||..|...|.||...||||.||.||
Mouse   326 ALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYP 390

  Fly   403 EAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRR--RELFVLLLLAFIF 465
            .|:..|..:..|:.:||.||:.|||||.|.|:|..||.|.|..|.....|  ||:.|.|..|..|
Mouse   391 RAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCF 455

  Fly   466 LCALPTMT-----YGGVVLVNFLNVY-GPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKP 524
            :..|..:|     .||:.:....:.| ..|..:|:..|.|...|.|.||.|||..|:..|:|.:|
Mouse   456 VIDLSMVTDVSGGKGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRP 520

  Fly   525 GLFWRICWTYISPVFLLTIFIFSIMGYKEML-GEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKF 588
            ..:.:.||::.:|:..:.||||:|:.|:.:: ...|.||.|...:|||...||:||:|:::: ..
Mouse   521 CPWMKWCWSFFTPLVCMGIFIFNIVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLL-GC 584

  Fly   589 FFASKGGCRQRLQESFQP 606
            ...:||...:|.|...||
Mouse   585 LLRAKGTMAERWQHLTQP 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	251/555 (45%)
Slc6a8	NP_598748.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		3/16 (19%)
Slc6a8	NP_598748.1	SLC6sbd_CT1	52..626	CDD:271397	251/555 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830