Protein Alignment SerT and slc6a16

DIOPT Version :10

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: XP_004916326.1
• Gene: slc6a16 / 100497867
• XenbaseID: XB-GENE-996340
• Length: 677
• Species: Xenopus tropicalis
• Alignment Length: 623
• Identity: 214/623 - (34%)
• Similarity: 321/623 - (51%)
• Gaps: 112/623 - (17%)

  Fly    49 KVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFL 113
            |..:.|....|...::.::......|.|||.|.:::||.:||:|.|||||||||:|:|||||:||
 Frog     3 KSLNDLEGSTAGESQLGLLPAESVARPTWGSKVQYILAQVGFSVGLGNVWRFPYLCHQNGGGSFL 67

  Fly   114 VPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWA 178
            :.|.|.|:..|:|||::|||.||..|.|.:.:||.|.|.|.|:|:|.|::..::.:|||.||||:
 Frog    68 LLYFLLLLIIGIPLFFLELAAGQSIRQGSIGVWKHISPRLAGIGFASCVVCGFVALYYNVIIGWS 132

  Fly   179 VYYLFASFTSKLPWTSCDNPWNTENCMQVTSENFTELATSPAKE-----FFERKVL------ESY 232
            ::|||.||...|||         |||  .|..|.|:..|..||.     |:.|..|      ||.
 Frog   133 LFYLFNSFHYPLPW---------ENC--PTLPNMTQEVTECAKSSNTTYFWYRSALNVTNTIESS 186

  Fly   233 KGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGA 297
            :.|     .|:...|.|..|    ||...:.||::|:|||::.:::.|||||...|:||:.|.||
 Frog   187 EMN-----WPMTGCLCLAWF----LVCGGMIKGIKSSGKVMYFSSVFPYVVLFCFLIRGLLLEGA 242

  Fly   298 DEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCL 362
            .:||:...||:.....|.:||..||:|:||:||.|||:::|.||||...|||:.||::.|.||.:
 Frog   243 ADGIRIMFTPKLEIWGNIQVWRQAATQVFFALGLGFGSVIAYSSYNDRQNNCHFDAILVSFINFM 307

  Fly   363 TSFLAGFVIFSVLGYMA-----YVQKTSIDKV--------------------------------- 389
            ||.||..|:|:|||:.|     :...|:.:|:
 Frog   308 TSILATLVVFAVLGFRANDLTRHCIDTNREKILYLISNGSLYENIVPMKNLTNSEYSQWYEITNN 372

  Fly   390 --------------------GLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGL 434
                                |:||.||.||.:.||:.....|.||||:|||||:.|||.:.||.:
 Frog   373 TLNLQQYGISDCRVEDVMNEGVEGTGLAFIAFTEAMTRFPASPFWSILFFLMLLNLGLSTMFGNM 437

  Fly   435 EAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVE 499
            :.:||.|.|.:| .:.:::.:|.::......|..|..:...|...|:..:.|...|.::.||..|
 Frog   438 QGIITPLLDNFP-YLRKKKTIFTVICCITGLLIGLIFVQRSGSYFVSMFDDYSATLPLIIVVIFE 501

  Fly   500 AAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIM--------------- 549
            ...|.|.||.:||..|:..|||.:|...::..|.|||.:.::.:.:.|::
 Frog   502 NIAVAWVYGAERFMDDIGGMLGHRPWRIYKYIWQYISILGMIGLLLASLIRMCIEYPRYQAWNQE 566

  Fly   550 -GYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIY 586
             ..||||    .||.|:  :|...:...|..:|:.|::
 Frog   567 QAKKEML----EYPPWA--LGMLTSLIIVAALPIPIVF 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	211/598 (35%)
slc6a16	XP_004916326.1	SLC5-6-like_sbd	28..599	CDD:444915	211/598 (35%)