DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and slc6a4

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_017946918.1	Gene:	slc6a4 / 100493853	XenbaseID:	XB-GENE-22062972	Length:	664	Species:	Xenopus tropicalis

Alignment Length:	583	Identity:	311/583 - (53%)
Similarity:	417/583 - (71%)	Gaps:	12/583 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ESPNNEDDSNEDDGDHTTPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVD 93
            |:|.|...:..|:|  :||   |..:.|......:.|...:.|  ||||.:|.:|||:|||:|||
Frog    75 EAPCNGMRNGGDEG--STP---TLTVLPACRAEIQHLQTEIGE--RETWSKKIDFLLSVIGYAVD 132

  Fly    94 LGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGY 158
            |||||||||:||||||||||:||.:..:|||:||||||||:||:||.||:|||::|||..||:||
Frog   133 LGNVWRFPYVCYQNGGGAFLIPYVIMAVFGGIPLFYMELAMGQYHRNGCISIWRKICPLFKGIGY 197

  Fly   159 AICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENC---MQVTSENFTELATSPA 220
            |||:|.:|:..|||||:.||:|||..||.|:||||||.|.|||.||   .|.:|..::..:.|||
Frog   198 AICMIALYVAFYYNTIMAWALYYLIFSFRSELPWTSCLNEWNTGNCTNYFQNSSVGWSNSSISPA 262

  Fly   221 KEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLI 285
            :||:.|.||:.:|..||..:|.:...|.||:..:|.:||||:||||:::||||||||..||:||.
Frog   263 EEFYTRLVLQIHKSKGLHDLGGISWQLTLCLLLIFTVVYFSIWKGVKTSGKVVWVTATFPYIVLA 327

  Fly   286 ILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCY 350
            :||:||.:||||..|:.:||.|:|.||..:.||:|||:|||||||||||.|||.:|||||:||||
Frog   328 LLLIRGATLPGAWRGVLFYLQPDWEKLLTTAVWVDAAAQIFFSLGPGFGVLLAFASYNKFHNNCY 392

  Fly   351 RDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLE-GPGLVFIVYPEAIATMSGSVFW 414
            :||||||::||:|||::|.|||:||||||.::...:.:|..: ||.|:||.|.||||.|..|.|:
Frog   393 QDALITSTVNCMTSFMSGLVIFTVLGYMAEMRNLDVSEVAKDTGPSLLFITYAEAIANMPASTFF 457

  Fly   415 SIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMTYGGVVL 479
            :||||||||||||||||.|||.:|||:.||:|.:.|:||||||.||::..||.||.|:|:||..:
Frog   458 AIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWGKRRELFVFLLISVCFLGALSTLTFGGAYM 522

  Fly   480 VNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIF 544
            |.....|..|.|:|.|||:||..|.||||:::|..||.:|||..||.||:|||..|.|:|||.|.
Frog   523 VKLFEEYATGPAVLTVVFLEAIAVSWFYGINQFCRDVREMLGFSPGWFWKICWVAICPLFLLFII 587

  Fly   545 IFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQESFQPE 607
            ...:....::....|.||.|:..:|:.:..||.:|:|.|::| ...::.|..::|..:|..||
Frog   588 CSFMSSPPDLRLFNYQYPSWTVVLGYCIGTSSFICVPAYMVY-LLTSTPGSIKERFLKSITPE 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	298/536 (56%)
slc6a4	XP_017946918.1	5HT_transport_N	48..91	CDD:367522	5/17 (29%)
slc6a4	XP_017946918.1	SLC5-6-like_sbd	113..649	CDD:382020	298/536 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	677	1.000	Domainoid score	I138
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	685	1.000	Inparanoid score	I696
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		otm47961
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060