Protein Alignment SerT and slc6a4

DIOPT Version :10

• Sequence 1: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: XP_017946918.1
• Gene: slc6a4 / 100493853
• XenbaseID: XB-GENE-22062972
• Length: 664
• Species: Xenopus tropicalis
• Alignment Length: 583
• Identity: 311/583 - (53%)
• Similarity: 417/583 - (71%)
• Gaps: 12/583 - (2%)

  Fly    29 ESPNNEDDSNEDDGDHTTPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVD 93
            |:|.|...:..|:|  :||   |..:.|......:.|...:.|  ||||.:|.:|||:|||:|||
 Frog    75 EAPCNGMRNGGDEG--STP---TLTVLPACRAEIQHLQTEIGE--RETWSKKIDFLLSVIGYAVD 132

  Fly    94 LGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGY 158
            |||||||||:||||||||||:||.:..:|||:||||||||:||:||.||:|||::|||..||:||
 Frog   133 LGNVWRFPYVCYQNGGGAFLIPYVIMAVFGGIPLFYMELAMGQYHRNGCISIWRKICPLFKGIGY 197

  Fly   159 AICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENC---MQVTSENFTELATSPA 220
            |||:|.:|:..|||||:.||:|||..||.|:||||||.|.|||.||   .|.:|..::..:.|||
 Frog   198 AICMIALYVAFYYNTIMAWALYYLIFSFRSELPWTSCLNEWNTGNCTNYFQNSSVGWSNSSISPA 262

  Fly   221 KEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLI 285
            :||:.|.||:.:|..||..:|.:...|.||:..:|.:||||:||||:::||||||||..||:||.
 Frog   263 EEFYTRLVLQIHKSKGLHDLGGISWQLTLCLLLIFTVVYFSIWKGVKTSGKVVWVTATFPYIVLA 327

  Fly   286 ILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCY 350
            :||:||.:||||..|:.:||.|:|.||..:.||:|||:|||||||||||.|||.:|||||:||||
 Frog   328 LLLIRGATLPGAWRGVLFYLQPDWEKLLTTAVWVDAAAQIFFSLGPGFGVLLAFASYNKFHNNCY 392

  Fly   351 RDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLE-GPGLVFIVYPEAIATMSGSVFW 414
            :||||||::||:|||::|.|||:||||||.::...:.:|..: ||.|:||.|.||||.|..|.|:
 Frog   393 QDALITSTVNCMTSFMSGLVIFTVLGYMAEMRNLDVSEVAKDTGPSLLFITYAEAIANMPASTFF 457

  Fly   415 SIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMTYGGVVL 479
            :||||||||||||||||.|||.:|||:.||:|.:.|:||||||.||::..||.||.|:|:||..:
 Frog   458 AIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWGKRRELFVFLLISVCFLGALSTLTFGGAYM 522

  Fly   480 VNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIF 544
            |.....|..|.|:|.|||:||..|.||||:::|..||.:|||..||.||:|||..|.|:|||.|.
 Frog   523 VKLFEEYATGPAVLTVVFLEAIAVSWFYGINQFCRDVREMLGFSPGWFWKICWVAICPLFLLFII 587

  Fly   545 IFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQESFQPE 607
            ...:....::....|.||.|:..:|:.:..||.:|:|.|::| ...::.|..::|..:|..||
 Frog   588 CSFMSSPPDLRLFNYQYPSWTVVLGYCIGTSSFICVPAYMVY-LLTSTPGSIKERFLKSITPE 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	298/536 (56%)
slc6a4	XP_017946918.1	5HT_transport_N	48..91	CDD:397524	5/17 (29%)
		SLC5-6-like_sbd	113..649	CDD:444915	298/536 (56%)