DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerT and slc6a11b

DIOPT Version :9

Sequence 1:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_017213744.2	Gene:	slc6a11b / 100150472	ZFINID:	ZDB-GENE-121116-2	Length:	617	Species:	Danio rerio

Alignment Length:	572	Identity:	253/572 - (44%)
Similarity:	371/572 - (64%)	Gaps:	22/572 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 KVTDPLAPKLAN------NERILVVSVTERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQN 107
            |..:.:.|:.||      |::.:|     ..|..|..|.||:|:|.|..:.|||||||||:||:|
Zfish    13 KAEESMDPESANPSAVRSNDKKVV-----NERGQWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKN 72

  Fly   108 GGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYN 172
            |||||.|||.:|.:..|:|:|::|.|||||...|.::.|:::||..:|:|||..:|:.::.:||.
Zfish    73 GGGAFFVPYVIFFVCCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYV 137

  Fly   173 TIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQVTSE---NFTE-LATSPAKEFFERKVLESYK 233
            .|:.||::|||..||::|||.||.:.||||||:...:|   |||. .:|||..||:||:||:.
Zfish   138 VILAWAIFYLFNCFTTELPWASCGHYWNTENCVDFNNESIANFTNPYSTSPVMEFWERRVLKI-- 200

  Fly   234 GNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGAD 298
            .:|::.:|.::..||||:...:|:.||.:|||.:|.||||:|||..||.:|:|||:||::||||.
Zfish   201 SSGIEEVGGLRWELALCLAIAWVICYFCIWKGPKSTGKVVYVTATFPYFMLLILLLRGITLPGAA 265

  Fly   299 EGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLT 363
            .|||:||.|:..:|.:.:||:||.:|||||.....|.|.||.|||.:|||||||.|:...:|..|
Zfish   266 NGIKFYLYPDISRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNSYNNNCYRDCLMLCCLNSGT 330

  Fly   364 SFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLD 428
            ||:|||.||||||:|||.|...|:.|...||||.||.||:|:..|..:..|:.:||:|||.||||
Zfish   331 SFVAGFAIFSVLGFMAYEQNVPIEAVAESGPGLAFIAYPKAVTMMPWAPLWAALFFMMLIFLGLD 395

  Fly   429 STFGGLEAMITALCDEYPRV--IGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVY-GPGL 490
            |.|..:|:::||:.|.||:.  :|.||||.:|.:....|...|..:|.||:.:....:.| ..|:
Zfish   396 SQFVCVESLVTAIVDMYPKTFRVGYRRELLILGMSIASFFLGLIMLTEGGMYVFQLFDSYAASGM 460

  Fly   491 AILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEM- 554
            .:|||...|:..:.|.||.|||..::|.|:|.||..|.:.||.:.:|.....||:|.::.||.:
Zfish   461 CLLFVAIFESICIGWVYGSDRFYLNIEDMIGYKPIFFIKWCWKFFTPGICTGIFLFFLIKYKPLK 525

  Fly   555 LGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQESFQP 606
            ....|.||||.|.:||.:..||::|||:.|::: .:.:||..|:|:::...|
Zfish   526 YNNVYTYPDWGYGIGWMMAMSSMVCIPLGILFQ-IWKTKGTFRERIKKLTTP 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	247/541 (46%)
slc6a11b	XP_017213744.2	SLC5-6-like_sbd	38..576	CDD:320982	246/540 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.930