DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBMY1B and NSR1

DIOPT Version :9

Sequence 1:	NP_001006121.1	Gene:	RBMY1B / 378948	HGNCID:	23914	Length:	496	Species:	Homo sapiens
Sequence 2:	NP_011675.1	Gene:	NSR1 / 853064	SGDID:	S000003391	Length:	414	Species:	Saccharomyces cerevisiae

Alignment Length:	297	Identity:	65/297 - (21%)
Similarity:	108/297 - (36%)	Gaps:	61/297 - (20%)

- Green bases have known domain annotations that are detailed below.

Human     3 EADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDR-TSKSRGFAFITFENPADAKNAAK 66
            |.:.|..:|:|.|:...:::.||..|...|.:....:|.:| |.:|||:.::.|||.:.|:.|.:
Yeast   163 ETEEPATIFVGRLSWSIDDEWLKKEFEHIGGVIGARVIYERGTDRSRGYGYVDFENKSYAEKAIQ 227

Human    67 DMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSQEGHLD 131
            :|.||.:.|:.|..:.:                  ...|:|:  :.|..:.|.....||....|.
Yeast   228 EMQGKEIDGRPINCDMS------------------TSKPAGN--NDRAKKFGDTPSEPSDTLFLG 272

Human   132 DGGYTPD----LKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSA---VARSNSWMGSQGPMSQRRE 189
            :..:..|    .::....|.:...|.|:.      |:...|..   |..||.....:...:.:.|
Yeast   273 NLSFNADRDAIFELFAKHGEVVSVRIPTH------PETEQPKGFGYVQFSNMEDAKKALDALQGE 331

Human   190 NYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSR 254
            .....|.|...||.|           ..|||....          |||:..|..|..     .:|
Yeast   332 YIDNRPVRLDFSSPR-----------PNNDGGRGG----------SRGFGGRGGGRG-----GNR 370

Human   255 GYRNHRSSRETR-DYAPPSRGHAYRDYGHSRRDESYS 290
            |:.....:|..| .:.|...|......|.||...|::
Yeast   371 GFGGRGGARGGRGGFRPSGSGANTAPLGRSRNTASFA 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBMY1B	NP_001006121.1	RRM	<1..189	CDD:223796	41/193 (21%)
		RRM_RBMX_like	7..85	CDD:240828	24/78 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..349		45/232 (19%)
		RBM1CTR	174..218	CDD:285341	8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..496
NSR1	NP_011675.1	RRM1_gar2	169..244	CDD:409881	23/74 (31%)
NSR1	NP_011675.1	RRM2_gar2	269..341	CDD:409882	13/77 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I2660
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910