DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpn8 and EIF3F

DIOPT Version :9

Sequence 1:	NP_001261167.1	Gene:	Rpn8 / 37894	FlyBaseID:	FBgn0002787	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_003745.1	Gene:	EIF3F / 8665	HGNCID:	3275	Length:	357	Species:	Homo sapiens

Alignment Length:	281	Identity:	78/281 - (27%)
Similarity:	146/281 - (51%)	Gaps:	22/281 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VIVHPLVLLSVVDHFNRMGKIGNQKRVVGVLLGCWRSKGVLDVSNSFAVPFDEDDKDKSVWFLDH 75
            |.:||::|.|:||.:.|..:  ...||:|.|||. ..|..::|:|.|:||.:|.:.:.:|   |.
Human    92 VRLHPVILASIVDSYERRNE--GAARVIGTLLGT-VDKHSVEVTNCFSVPHNESEDEVAV---DM 150

  Fly    76 DYLENMYGMFKKVNARERVVGWYHTGPKLHQNDIAINELVRRYCPNSVLVIIDAKPKDLGLPTEA 140
            ::.:|||.:.|||:..|.::|||.||..:.::.:.|:|...|..||.:.:.:|...::..:..:|
Human   151 EFAKNMYELHKKVSPNELILGWYATGHDITEHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKA 215

  Fly   141 YISVEEVHDDGSPTSKTFEHVPSEIGAEEAEEVGVEHLLRDI--KDTTVGSLSQKITNQLMGLKG 203
            |:|. .:...|......|..:..:....:.|.:||:.:::..  .:..:|     :::.|..:.|
Human   216 YVST-LMGVPGRTMGVMFTPLTVKYAYYDTERIGVDLIMKTCFSPNRVIG-----LSSDLQQVGG 274

  Fly   204 LNAQLRD----IKQYLQRVGDSKMPINHQIVYQLQDIFNLLPDITNDQFTGTMYVKTNDQMLVVY 264
            .:|:::|    :.||.:.|...|:..::.:...|..:.|.:|.|..|.|...:....||.::|.|
Human   275 ASARIQDALSTVLQYAEDVLSGKVSADNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTY 339

  Fly   265 LASMVRSIIALHNLINNKLAN 285
            ||::.:|.|||    |.||.|
Human   340 LANLTQSQIAL----NEKLVN 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn8	NP_001261167.1	PLN03246	7..308	CDD:215645	78/281 (28%)
Rpn8	NP_001261167.1	MPN_RPN7_8	9..290	CDD:163693	78/281 (28%)
EIF3F	NP_003745.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82
EIF3F	NP_003745.1	MPN_eIF3f	92..354	CDD:163695	75/277 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D455272at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920