DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn8 and Mpnd

DIOPT Version :9

Sequence 1:	NP_001261167.1	Gene:	Rpn8 / 37894	FlyBaseID:	FBgn0002787	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	XP_038940132.1	Gene:	Mpnd / 681944	RGDID:	1589335	Length:	488	Species:	Rattus norvegicus

Alignment Length:	254	Identity:	50/254 - (19%)
Similarity:	81/254 - (31%)	Gaps:	100/254 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SVNK-------VIVHPLVLLSVVDHFNRMGKIGNQKRVVGVLLGCWRSKGVLDVSNSF-----AV 59
            ::||       |..:.|.||....|..|       ..|||.|.|.|      |::|..     |.
  Rat   249 AINKFQPFNVAVSSNVLFLLDFHCHLTR-------SEVVGYLGGRW------DINNQMLTVLRAF 300

  Fly    60 P----FDEDDKDKSVWFLDHDYLENMYGMFKKVNARERVVGWYHT------GPKLHQNDIAINEL 114
            |    ..:.|...:|....|..| .:.|:        .:|||||:      .|.|...|..:...
  Rat   301 PCRSRLGDPDTAATVEEEIHQVL-FLRGL--------SLVGWYHSHPHSPAAPSLQDIDAQMEYQ 356

  Fly   115 VR----------------------------RYCPNSVLVIID-AKPKDLGLPTE---AYISVEEV 147
            :|                            :.||..|:...: .:|.|.|:|.:   ||:....:
  Rat   357 LRLQGSNNGFQPCLALLCSPYYSGNPGPESKICPFWVMPPPEQQRPSDYGIPMDVEMAYVQDSFL 421

  Fly   148 HDD-------------GSPTSKTF------EH-----VPSEIGAEEAEEVGVEHLLRDI 182
            .:|             |:|....|      ||     :...:.:...::.|:.|:|..:
  Rat   422 TNDVLQEMMMLVEFYKGAPDLVKFQEAWSPEHTYLDKLKMSLASRTPKDQGMCHVLEQV 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn8	NP_001261167.1	PLN03246	7..308	CDD:215645	50/254 (20%)
Rpn8	NP_001261167.1	MPN_RPN7_8	9..290	CDD:163693	50/252 (20%)
Mpnd	XP_038940132.1	RAMA	57..157	CDD:408526
Mpnd	XP_038940132.1	MPN_2A_DUB	252..437	CDD:163698	41/206 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900