DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn8 and CG2224

DIOPT Version :9

Sequence 1:	NP_001261167.1	Gene:	Rpn8 / 37894	FlyBaseID:	FBgn0002787	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster

Alignment Length:	199	Identity:	36/199 - (18%)
Similarity:	70/199 - (35%)	Gaps:	80/199 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 LSQKITNQLMGLKGLNAQLRDIKQYLQRVG-----DSKMPINHQIVYQLQDIFNLLPDITNDQFT 249
            :|:.:.|..||    :.:.::..::|...|     |..||:
  Fly     1 MSKAVNNMSMG----DVEPQERMKHLSHCGNLIEVDKNMPV------------------------ 37

  Fly   250 GTMYVKTNDQML----------------VVYLASMVRSIIALHNLINNKLANRDAEEGKSDSKEA 298
             |.|.::..:||                ::||..|        .|...|:  |...:..|...|.
  Fly    38 -TRYYRSGTEMLRMANVYLREGNHENAFILYLRYM--------TLFIEKI--RQHPDYGSVKAEV 91

  Fly   299 KEKNKDSKDKDNKETKDKDGK------------KAEEKADKGKDEGGKGSRKXERKKKRKPRRKR 351
            ::.|:..||:....|:....|            .|.::|::.|:        .||:::|:..|:|
  Fly    92 RDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLASKEAERVKE--------LERERERERERQR 148

  Fly   352 KKQR 355
            :|:|
  Fly   149 QKER 152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn8	NP_001261167.1	PLN03246	7..308	CDD:215645	23/138 (17%)
Rpn8	NP_001261167.1	MPN_RPN7_8	9..290	CDD:163693	19/120 (16%)
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	22/137 (16%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810