DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn8 and Psmd7

DIOPT Version :9

Sequence 1:	NP_001261167.1	Gene:	Rpn8 / 37894	FlyBaseID:	FBgn0002787	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_001100896.1	Gene:	Psmd7 / 307821	RGDID:	1306902	Length:	320	Species:	Rattus norvegicus

Alignment Length:	328	Identity:	250/328 - (76%)
Similarity:	288/328 - (87%)	Gaps:	9/328 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSQEVSVNKVIVHPLVLLSVVDHFNRMGKIGNQKRVVGVLLGCWRSKGVLDVSNSFAVPFDEDD 65
            ||  |::|.||:|||||||||||||||:||:||||||||||||.|:.| ||||||||||||||||
  Rat     1 MP--ELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKK-VLDVSNSFAVPFDEDD 62

  Fly    66 KDKSVWFLDHDYLENMYGMFKKVNARERVVGWYHTGPKLHQNDIAINELVRRYCPNSVLVIIDAK 130
            ||.|||||||||||||||||||||||||:|||||||||||:||||||||::||||||||||||.|
  Rat    63 KDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVK 127

  Fly   131 PKDLGLPTEAYISVEEVHDDGSPTSKTFEHVPSEIGAEEAEEVGVEHLLRDIKDTTVGSLSQKIT 195
            |||||||||||||||||||||:|||||||||.||||||||||||||||||||||||||:|||:||
  Rat   128 PKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRIT 192

  Fly   196 NQLMGLKGLNAQLRDIKQYLQRVGDSKMPINHQIVYQLQDIFNLLPDITNDQFTGTMYVKTNDQM 260
            ||:.||||||::|.||:.||::|...|:||||.|:|||||:||||||.:..:|....|:||||||
  Rat   193 NQVHGLKGLNSKLLDIRTYLEKVASGKLPINHHIIYQLQDVFNLLPDASLQEFVKAFYLKTNDQM 257

  Fly   261 LVVYLASMVRSIIALHNLINNKLANRDAEEGKSDSKEAKEKNKDSKD-KDNKETKDKDGKKAEEK 324
            :||||||::||::|||||||||:||||||:     ||.:||.:..|: ||:||.:..|.||.|:|
  Rat   258 VVVYLASLIRSVVALHNLINNKIANRDAEK-----KEGQEKEESKKERKDDKEKEKSDAKKEEKK 317

  Fly   325 ADK 327
            ..|
  Rat   318 EKK 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn8	NP_001261167.1	PLN03246	7..308	CDD:215645	237/301 (79%)
Rpn8	NP_001261167.1	MPN_RPN7_8	9..290	CDD:163693	230/280 (82%)
Psmd7	NP_001100896.1	MPN_RPN7_8	7..285	CDD:163693	228/278 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340985
Domainoid	1	1.000	218	1.000	Domainoid score	I2585
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2104
Inparanoid	1	1.050	509	1.000	Inparanoid score	I1273
OMA	1	1.010	-	-		QHG53821
OrthoDB	1	1.010	-	-		D1275837at2759
OrthoFinder	1	1.000	-	-		FOG0003980
OrthoInspector	1	1.000	-	-		oto96251
orthoMCL	1	0.900	-	-		OOG6_102054
Panther	1	1.100	-	-	LDO	PTHR10540
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2737
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810