DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn8 and Psmd7

DIOPT Version :9

Sequence 1:	NP_001261167.1	Gene:	Rpn8 / 37894	FlyBaseID:	FBgn0002787	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_034947.1	Gene:	Psmd7 / 17463	MGIID:	1351511	Length:	321	Species:	Mus musculus

Alignment Length:	328	Identity:	251/328 - (76%)
Similarity:	289/328 - (88%)	Gaps:	9/328 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSQEVSVNKVIVHPLVLLSVVDHFNRMGKIGNQKRVVGVLLGCWRSKGVLDVSNSFAVPFDEDD 65
            ||  |::|.||:|||||||||||||||:||:||||||||||||.|:.| ||||||||||||||||
Mouse     1 MP--ELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKK-VLDVSNSFAVPFDEDD 62

  Fly    66 KDKSVWFLDHDYLENMYGMFKKVNARERVVGWYHTGPKLHQNDIAINELVRRYCPNSVLVIIDAK 130
            ||.|||||||||||||||||||||||||:|||||||||||:||||||||::||||||||||||.|
Mouse    63 KDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVK 127

  Fly   131 PKDLGLPTEAYISVEEVHDDGSPTSKTFEHVPSEIGAEEAEEVGVEHLLRDIKDTTVGSLSQKIT 195
            |||||||||||||||||||||:|||||||||.||||||||||||||||||||||||||:|||:||
Mouse   128 PKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRIT 192

  Fly   196 NQLMGLKGLNAQLRDIKQYLQRVGDSKMPINHQIVYQLQDIFNLLPDITNDQFTGTMYVKTNDQM 260
            ||:.||||||::|.||:.||::|...|:||||||:|||||:||||||.:..:|....|:||||||
Mouse   193 NQVHGLKGLNSKLLDIRSYLEKVASGKLPINHQIIYQLQDVFNLLPDASLQEFVKAFYLKTNDQM 257

  Fly   261 LVVYLASMVRSIIALHNLINNKLANRDAEEGKSDSKEAKEKNKDSKD-KDNKETKDKDGKKAEEK 324
            :||||||::||::|||||||||:||||||:     ||.:||.:..|: ||:||.:..|..|.|||
Mouse   258 VVVYLASLIRSVVALHNLINNKIANRDAEK-----KEGQEKEESKKERKDDKEKEKSDAAKKEEK 317

  Fly   325 ADK 327
            .:|
Mouse   318 KEK 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn8	NP_001261167.1	PLN03246	7..308	CDD:215645	238/301 (79%)
Rpn8	NP_001261167.1	MPN_RPN7_8	9..290	CDD:163693	231/280 (83%)
Psmd7	NP_034947.1	PLN03246	6..284	CDD:215645	229/278 (82%)
		MPN_RPN7_8	7..285	CDD:163693	229/278 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..321		21/45 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837267
Domainoid	1	1.000	218	1.000	Domainoid score	I2655
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2104
Inparanoid	1	1.050	512	1.000	Inparanoid score	I1300
Isobase	1	0.950	-	0	Normalized mean entropy	S277
OMA	1	1.010	-	-		QHG53821
OrthoDB	1	1.010	-	-		D455272at33208
OrthoFinder	1	1.000	-	-		FOG0003980
OrthoInspector	1	1.000	-	-		oto92689
orthoMCL	1	0.900	-	-		OOG6_102054
Panther	1	1.100	-	-	LDO	PTHR10540
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1207
SonicParanoid	1	1.000	-	-		X2737
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790