Protein Alignment Rpn8 and COPS6

DIOPT Version :10

• Sequence 1: NP_001261167.1
• Gene: Rpn8 / 37894
• FlyBaseID: FBgn0002787
• Length: 358
• Species: Drosophila melanogaster
• Sequence 2: NP_006824.2
• Gene: COPS6 / 10980
• HGNCID: 21749
• Length: 327
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 75/284 - (26%)
• Similarity: 146/284 - (51%)
• Gaps: 17/284 - (5%)

  Fly    11 VIVHPLVLLSVVDHFNRM-GKIGNQKRVVGVLLGCWRSKGVLDVSNSFAVPFDEDDKDKSVWFLD 74
            |.:||||:|::.||:.|| .:.|...:|:|.|:|....:.: :|.|||.: .....::|.:  :|
Human    41 VALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRNI-EVMNSFEL-LSHTVEEKII--ID 101

  Fly    75 HDYLENMYGMFKKVNARERVVGWYHTGPKLHQNDIAINELVRRYCPNSVLVIIDAKPKDLGLPTE 139
            .:|.......||:|......:|||.||.....:||.:::.|.....:.:.:.::...|...||..
Human   102 KEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVS 166

  Fly   140 AYISVEEVHDDGSPTSKTFEHVPSEIGAEEAEEVGVEHLLRDIKDTTVGS-----LSQKITNQLM 199
            .:.||.:: .:|..| ..|..:...:..||||.:||:|:.|   .|..||     :::.:..|..
Human   167 VFESVIDI-INGEAT-MLFAELTYTLATEEAERIGVDHVAR---MTATGSGENSTVAEHLIAQHS 226

  Fly   200 GLKGLNAQLRDIKQYLQRVGDSKMPINHQIVYQLQDIFNLLPDITNDQFTGTMYVKTNDQMLVVY 264
            .:|.|:::::.|.:|::.....::|.||:|:.:...:.:.||.::.|:|....|.:.||..|:.|
Human   227 AIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAY 291

  Fly   265 LASMVRSIIALHNLIN--NKLANR 286
            |.::.::...::..:|  |.|.:|
Human   292 LGTITKTCNTMNQFVNKFNVLYDR 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpn8	NP_001261167.1	MPN_RPN7_8	9..290	CDD:163693	75/284 (26%)
COPS6	NP_006824.2	MPN_CSN6	39..321	CDD:163694	75/284 (26%)
		Interaction with Vpr	211..327		24/105 (23%)