Protein Alignment Rpn8 and PSMD14

DIOPT Version :10

• Sequence 1: NP_001261167.1
• Gene: Rpn8 / 37894
• FlyBaseID: FBgn0002787
• Length: 358
• Species: Drosophila melanogaster
• Sequence 2: NP_005796.1
• Gene: PSMD14 / 10213
• HGNCID: 16889
• Length: 310
• Species: Homo sapiens
• Alignment Length: 320
• Identity: 70/320 - (21%)
• Similarity: 118/320 - (36%)
• Gaps: 79/320 - (24%)

  Fly     7 SVNKVIVHPLVLLSVVDHFNRMGKIGNQKRVVGVLLGCWRSKGVLDVSNSFAVPFDEDDKDKSVW 71
            :..:|.:..|.||.::.|    |:.|....|:|::||.:.....:.|.:.||:|  :.....||.
Human    27 TAEQVYISSLALLKMLKH----GRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMP--QSGTGVSVE 85

  Fly    72 FLDHDYLENMYGMFKKVNARERVVGWYHTGPK----LHQNDIAINELVRRYCPNSVLVIIDAKPK 132
            .:|..:...|..|.|:....|.||||||:.|.    |...||...:........:|.|::|
Human    86 AVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVD---- 146

  Fly   133 DLGLPTEAYISVEEVHDDGSPTSKTFEHVPSE---IGAEEAEEVGVEHLLRDIKDTTVGSLSQKI 194
                |.:   ||:     |......|..:.:.   :|.|..:..           :.:|.|::..
Human   147 ----PIQ---SVK-----GKVVIDAFRLINANMMVLGHEPRQTT-----------SNLGHLNKPS 188

  Fly   195 TNQLMGLKGLNAQLRDIK-QYLQRVGDSKMPIN-HQIVYQ----LQDIFNLLPDITNDQFTGTMY 253
            ...|  :.|||.....|. .|.:...:.||.:| |:..:.    |||.              :.:
Human   189 IQAL--IHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDY--------------SEH 237

  Fly   254 VKTNDQMLVVYLASMVRSIIALHNLINNKLANRD---------AEEGKSDSKEAKEKNKD 304
            .|.|:        |:|:.::.|....|..:...|         ...||.|.|...|::.|
Human   238 CKHNE--------SVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVD 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpn8	NP_001261167.1	MPN_RPN7_8	9..290	CDD:163693	64/302 (21%)
PSMD14	NP_005796.1	MPN_RPN11_CSN5	21..286	CDD:163700	68/315 (22%)
		JAMM motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01182	113..126		3/12 (25%)