DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slik and SLK

DIOPT Version :9

Sequence 1:	NP_726441.1	Gene:	Slik / 37893	FlyBaseID:	FBgn0035001	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_055535.2	Gene:	SLK / 9748	HGNCID:	11088	Length:	1235	Species:	Homo sapiens

Alignment Length:	1377	Identity:	472/1377 - (34%)
Similarity:	707/1377 - (51%)	Gaps:	226/1377 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFITNLKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAA 65
            |||. |.:|:|.|  |..|||:.|.::|.|.:|.:|||::|||||||||||||||:||....|||
Human     1 MSFF-NFRKIFKL--GSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAA 62

  Fly    66 KMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPL 130
            |:...:.||.|.|:|||||||:...|||||:|.:||..::.||:|||:|.|||:|::|:|||:||
Human    63 KVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPL 127

  Fly   131 TEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIG 195
            ||.||..|||...:.|.:||.||:|||||||||:|.|::|.:|||||||||||..|:|:.|:|||
Human   128 TESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIG 192

  Fly   196 TPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQ 260
            ||||||||:|:|||.:|.|||:|.|:|||||||||:|::|||:.|::||||||||.|||||.|.|
Human   193 TPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQ 257

  Fly   261 PSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDA-KPIKDLLLEYKAEVVEEVVD--- 321
            |||||..|.|||||.|.|:...|.||..|:||.|:  .:|: |||::|:.|.||||.|||.|
Human   258 PSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV--TVDSNKPIRELIAEAKAEVTEEVEDGKE 320

  Fly   322 -DETEEPRNSALQLDLD---DDSASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAA 382
             ||.||..|| |.:...   ....|:.|.:.||| .....||....|:::.|:|      .....
Human   321 EDEEEETENS-LPIPASKRASSDLSIASSEEDKL-SQNACILESVSEKTERSNS------EDKLN 377

  Fly   383 AATTTTKATTPDRP--------NHTKDDNAEAAAQQPPHTKVPAPAPPSSQQTPPPQVQQPPTPP 439
            :.....|.|| |.|        .|..|...||..:....|.|    ...:::...|:::..|...
Human   378 SKILNEKPTT-DEPEKAVEDINEHITDAQLEAMTELHDRTAV----IKENEREKRPKLENLPDTE 437

  Fly   440 AQPTAAVLQKKPEDVAAVAETSEKT-----ESDKKHFVKKGKAPPPPSPLGLANAKPAASDSQTS 499
            .|.|.        |:.:|:|..|..     |::.:|.:|.            ...|.........
Human   438 DQETV--------DINSVSEGKENNIMITLETNIEHNLKS------------EEEKDQEKQQMFE 482

  Fly   500 PKKLATPEPTSPVTTAIEVAIGQEAMEPKPQPPSPTASSIVSVQSVASSSSSGSVSNAVLSSSTS 564
            .|.:.:.|....:...::: :.||           |.....::|:|.|...        |:...:
Human   483 NKLIKSEEIKDTILQTVDL-VSQE-----------TGEKEANIQAVDSEVG--------LTKEDT 527

  Fly   565 LITINSDPPTPHHHQPLPPQPQHLILPNSLESVSQITVVTSTHPPVIIDNSVMPPQNEVIIVSND 629
            ...:..|..|                                             |.:||..::|
Human   528 QEKLGEDDKT---------------------------------------------QKDVISNTSD 547

  Fly   630 MNKSTHLHESSTDDDFPSLDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQTSST------ 688
            :..:....:.:...|    :||..|..:...|:   ::.|.:.  ::..|...|:...|
Human   548 VIGTCEAADVAQKVD----EDSAEDTQSNDGKE---VVEVGQK--LINKPMVGPEAGGTKEVPIK 603

  Fly   689 --VHARKLDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHVSVVTVGDEGVKVKDSSN 751
              |...:::|.:         :.:.|.|:         |:::||.:.....|.|:| :....|:.
Human   604 EIVEMNEIEEGK---------NKEQAINS---------SENIMDINEEPGTTEGEE-ITESSSTE 649

  Fly   752 ELVKR------QPNGVGIVPEDVNIIVNRFKQEKRSPDSSLSENGSVRGRRGIEVLVGGSGGSDV 810
            |:..|      ....:|...:|.:.:..:..:||:....|:.:...|
Human   650 EMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEV------------------ 696

  Fly   811 DSIGTNTSQESRHETDHNNKQQYPAAALMPPPPPSLTNNHNHETID--EEEEVVIRPKARVPAVV 873
                |..||.:.           |...|:|....:..:..|.|.|.  .:.|.::.|::..|...
Human   697 ----TVVSQPTE-----------PQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKEN 746

  Fly   874 KSANAQGLTKE---------------------EIELRNLR--KKTRKRTRKFEIDGVQMTTTTSR 915
            .:.:..|.|.:                     .|.|:..|  |||.|:||||.:|||:::.|||:
Human   747 DNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSK 811

  Fly   916 VIYGDDENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQQAKEQQDRRFEQERSSLEKTY 980
            ::  .|.:.:..:....|:||||||:.|||:|::.|.:|:.|.||.:||..||||||..|.::.|
Human   812 IV--TDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQY 874

  Fly   981 EADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQEIRLLKQEVDLFPKD 1045
            :.:::.|.:|.||.:|:.||...|.||..:|||:.|||:||..|:..||...:.:..||:..||:
Human   875 DQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKE 939

  Fly  1046 KRKDEFKQRRSAMELDHEEKERAFLDSLKERHELLLRRLSEKHRDHLATINRNFLQQKQNAMRTR 1110
            .||:..|:|:..:......:|:.|:...::..:..|:::.::.:..||.|.|..|..||..||.|
Human   940 LRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAR 1004

  Fly  1111 EALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQVKRMLQRKEEDMVKKQTMEKR 1175
            ||.:|||||:.|.|:|||.|:.:|:..||||||::.|||||.:|::|..||..|::..:||.|:.
Human  1005 EAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERA 1069

  Fly  1176 ALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKFQEQEKKRYMQEERRFEVKHQKQLEEL 1240
            .|||..|:|.|.|..||::||||::...|:.:||::|:|..||:||...|......||:.|:.:|
Human  1070 RLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDL 1134

  Fly  1241 RATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREWREQLVPRKQELNRQIKLAIDQ 1305
            :...|:.::||.||||||...|||||..||.|:||....||:||||:|.|||:.|..:....:.:
Human  1135 QLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQE 1199

  Fly  1306 HEKRFGLVTNRE 1317
            .|..|.:....|
Human  1200 QEVFFKMTGESE 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	173/279 (62%)
		S_TKc	37..295	CDD:214567	165/257 (64%)
		PKK	958..1095	CDD:289257	46/136 (34%)
		PKK	1126..1266	CDD:289257	63/139 (45%)
SLK	NP_055535.2	STKc_SLK	28..309	CDD:270811	174/282 (62%)
		S_TKc	34..292	CDD:214567	165/257 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..351		16/42 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..393		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..441		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..539		3/72 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..760		32/198 (16%)
		PKK	852..990	CDD:289257	46/137 (34%)
		PKK	1020..1160	CDD:289257	63/139 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I999
eggNOG	1	0.900	-	-		E1_KOG0579
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49250
OrthoDB	1	1.010	-	-		D365746at33208
OrthoFinder	1	1.000	-	-		FOG0002520
OrthoInspector	1	1.000	-	-		otm42032
orthoMCL	1	0.900	-	-		OOG6_105446
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3487
SonicParanoid	1	1.000	-	-		X1895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.820