DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slik and KCC4

DIOPT Version :9

Sequence 1:	NP_726441.1	Gene:	Slik / 37893	FlyBaseID:	FBgn0035001	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_009907.2	Gene:	KCC4 / 850334	SGDID:	S000000529	Length:	1037	Species:	Saccharomyces cerevisiae

Alignment Length:	1105	Identity:	232/1105 - (20%)
Similarity:	403/1105 - (36%)	Gaps:	325/1105 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHM-----------VEIDILSEIK 90
            |::...||.|:.|||..|||:......|.|:.......|..:|.           .||.|:..:.
Yeast    21 WKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLS 85

  Fly    91 HPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVI 155
            |||::.||:.:..::.|::::||.:.|.|.:::|: ..||.|.:.....:.:..|:::.|...::
Yeast    86 HPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVD-HGPLPEREAINCFRQIIIGISYCHALGIV 149

  Fly   156 HRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKH----DTFIGTPYWMAPELVLCETFRDNPYD 216
            |||||..|:||.....:|:||||::|     :|..    :|..|:|::.|||:|     ...||:
Yeast   150 HRDLKPENLLLDSFYNIKIADFGMAA-----LQTDADLLETSCGSPHYAAPEIV-----SGLPYE 204

  Fly   217 -HKVDIWSLGITLIELAQMEPP-NSEMSPMR-VLLKIQKSEPPKLEQP--SRWSKEFNDFLKKSL 276
             ...|:||.|:.|..|.....| :.|...:| :|||:||.:   .|.|  :..|::..|.:.|.|
Yeast   205 GFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQ---FEMPNDTEISRDAQDLIGKIL 266

  Fly   277 VKDPQVRPTTDVLMQHAFINRN---LDAKPIKDLLLE---------------------------- 310
            |.||:.|.....::.|..:.:.   .|:|.||||..|
Yeast   267 VVDPRQRIKIRDILSHPLLKKYQTIKDSKSIKDLPRENTYLYPLADSNNHTSASIDDSILQNLVV 331

  Fly   311 -----YKAEVVEEVVDDET---------------------------------EEPRNSALQLDLD 337
                 :..::|.::.::.|                                 :..|:|.|.   .
Yeast   332 LWHGRHADDIVSKLKENGTNKEKILYALLYRFKLDSVRGSNKKNRNKIKKTKKNKRSSTLS---S 393

  Fly   338 DDSASLQSQDIDKLPGTPTSILRDAKE------------QSQPSSSLPI----AAAATAAAAATT 386
            ..|..|.::.|...|...|| .|.::|            .|.|:.|.||    :...|....|:.
Yeast   394 SSSLLLNNRSIQSTPRRRTS-KRHSREFSSSRKRSSFLLSSNPTDSSPIPLRSSKRITHINVASA 457

  Fly   387 TTKATTPDRPNHTKDDNAEAAAQQ---PPHTKVPAPAPPSSQQTPPPQVQQPPTPPAQPTAAVLQ 448
            .|:||....||..|.::.:.::::   .|:||                            .:.|.
Yeast   458 NTQATPSGVPNPHKRNSKKRSSKRLSYMPNTK----------------------------RSSLT 494

  Fly   449 KKPEDVAAVAETSEKTESDKKHFVKKGKAPPPPSPLGLANAKPAASDSQTSPKKLATPEPTSPVT 513
            .|     :::..:...:.|...:::|             :||..:|:..|...::..||
Yeast   495 SK-----SLSNFTNLIDDDDWEYIEK-------------DAKRTSSNFATLIDEIFEPE------ 535

  Fly   514 TAIEVAIGQEA-MEPKPQPPSPTASSIVSVQSVASSSSSGSVSNAVLSSSTSLITINSDPPTP-- 575
             ..|:|..::| ::.|.|.....:   |:.|.:........||:.:    ..|..||....:|
Yeast   536 -KFELAKREKAELQRKVQEAKRQS---VNAQKINEDEFGSEVSDGM----KELKKINDKVSSPLI 592

  Fly   576 --HHHQPLPPQPQHLILPN--SLESVSQ--------ITVVTSTHPPVIIDNSVMPPQNEVIIVSN 628
              ...|....|....:|.|  .|.|.::        :|.||.|.|..:.:.:.:....|..|:..
Yeast   593 NYEFSQQELLQDIDTLLTNRYQLSSYTRPISRLDPGLTPVTETLPNNLKEKTALLQDTEKKIIET 657

  Fly   629 DMNKSTHLHE--------SSTDDDFPSLDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQT 685
             :.:|..|..        |....:...:::|...:|||        |..|:
Yeast   658 -IRRSKFLGSLLNVRGGLSPGKSELAPIEESPIVSTTP--------LIYND-------------- 699

  Fly   686 SSTVHARKLDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHVSVVTVGDEGVKVKDSS 750
              .:..|::.:.||    |.:......:.||:...|            |..:...|   .:||.:
Yeast   700 --RMEPRRISDVEV----PHFTRKSKHFTTANNRRS------------VLSLYAKD---SIKDLN 743

  Fly   751 NELVKRQPNGVGIVPEDVNIIVNRFKQEKRSPDSSLSENGSVRGRRGIEVLVGGS-GGSDV--DS 812
            ..|:|..|:   :.|:      .....|.||.|..::|  |:...|.|:.....| .|.:|  |:
Yeast   744 EFLIKEDPD---LPPQ------GSTDNESRSEDPEIAE--SITDSRNIQYDEDDSKDGDNVNNDN 797

  Fly   813 I------GTNTSQESRHETDHNNKQQYPAAALMPP----PPPSLTNNHNHETIDEEEEVVIRPKA 867
            |      |...|||  ::....|..|.|.:....|    ..|||::...
Yeast   798 ILSDFPQGVGISQE--YDMKDKNPNQSPISKSAEPTLVVKLPSLSSFQG---------------- 844

  Fly   868 RVPAVVKSANAQGLTKEE---IELRNLRKKTRKRTRKFEIDGVQMTTTTSRVI--YGDDENGRIY 927
                  |:|:..||.:.|   :.|.:|...........| ||.:..|.:.::.  ..||:   :.
Yeast   845 ------KNASGLGLYQREPSKVTLPSLTSNNSSVGENIE-DGAEKGTESEKIAASLSDDD---LK 899

  Fly   928 DDHDFRKQELRELK----------LLQKQEKKQQTELHLKEQQAKEQQDRRFEQERSSLE--KTY 980
            :|:|.:..:.....          ||:|..|.:..||   |..||..:.|.:|.....||  |.|
Yeast   900 EDNDKKDNDTVNAPTTVKKPPNSVLLKKFSKGKILEL---EIHAKIPEKRLYEGLHKLLEGWKQY 961

Fly 981 980
Yeast 962 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	88/295 (30%)
		S_TKc	37..295	CDD:214567	82/277 (30%)
		PKK	958..1095	CDD:289257	9/25 (36%)
		PKK	1126..1266	CDD:289257
KCC4	NP_009907.2	PKc_like	19..285	CDD:419665	82/277 (30%)
KCC4	NP_009907.2	Kcc4p_like_C	920..1034	CDD:213379	15/45 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I1145
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050