DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slik and STK10

DIOPT Version :9

Sequence 1:	NP_726441.1	Gene:	Slik / 37893	FlyBaseID:	FBgn0035001	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_005981.3	Gene:	STK10 / 6793	HGNCID:	11388	Length:	968	Species:	Homo sapiens

Alignment Length:	1339	Identity:	429/1339 - (32%)
Similarity:	619/1339 - (46%)	Gaps:	396/1339 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFITNLKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAA 65
            |:| .|.:::..|...|.:|.|.|.:::.|.||.|.||:|||||||||||||||::||....|||
Human     1 MAF-ANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAA 64

  Fly    66 KMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPL 130
            |:.:.:.||.|.|::|||:||:...||.||:|..|:..|.|||::||:|.|||:|:||:||::.|
Human    65 KVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGL 129

  Fly   131 TEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIG 195
            |||||..||:.|.|.|.|||..::|||||||||||:|:||.::||||||||||..|:||.|:|||
Human   130 TEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIG 194

  Fly   196 TPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQ 260
            ||||||||:|:|||.:|.|||:|.|||||||||||:||:|||:.|::||||||||.||:||.|..
Human   195 TPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLT 259

  Fly   261 PSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVD--DE 323
            ||:||.||.||||.:|.|:|:.||:...|::|.|::.....|.:::|:.|.||||:||:.|  ||
Human   260 PSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDE 324

  Fly   324 TEEPRNSALQLDLDDDSASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAAATTTT 388
            .||.       |..|.:::|::...:....:|.|:..|...:..||
Human   325 GEEE-------DAVDAASTLENHTQNSSEVSPPSLNADKPLEESPS------------------- 363

  Fly   389 KATTPDRPNHTKDDNAEAAAQQPPHTKVPAPAPPSSQQTPPPQVQQPPTPPAQPTAAVLQKKPED 453
               ||..|:.::|...|..:|         |:...|.||..|.|..|..
Human   364 ---TPLAPSQSQDSVNEPCSQ---------PSGDRSLQTTSPPVVAPGN---------------- 400

  Fly   454 VAAVAETSEKTESDKKHFVKKGKAPPPPSPLGLANAKPAASDSQTSPKKLATPEPTSPVTTAIEV 518
                               :.|.|.|.|    |..::|.:.|::              :..|.|.
Human   401 -------------------ENGLAVPVP----LRKSRPVSMDAR--------------IQVAQEK 428

  Fly   519 AIGQEAMEPKPQPPSPTASSIVSVQSVASSSSSGSVSNAVLSSSTSLITINSDPPTPHHHQPLPP 583
            .:.::..:..|               .|:.|...|.|.
Human   429 QVAEQGGDLSP---------------AANRSQKASQSR--------------------------- 451

  Fly   584 QPQHLILPNS--LESVSQITVVTSTHPPVIIDNSVMPPQNEVIIVSNDMNKSTHLHESSTDDDFP 646
                   |||  ||::.
Human   452 -------PNSSALETLG------------------------------------------------ 461

  Fly   647 SLDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQTSSTVHARKLDESEVLIVSPSYADDDS 711
              .:.|.:.:..|            ||...|.|..:                           ||
Human   462 --GEKLANGSLEP------------PAQAAPGPSKR---------------------------DS 485

  Fly   712 AYNTASGSHSHDHSDHLMDTSHVSVVTVGDEGVKVKDSSNELVKRQPNGVGIVPEDVNIIVNRFK 776
            ..::...|.|.|:
Human   486 DCSSLCTSESMDY---------------------------------------------------- 498

  Fly   777 QEKRSPDSSLSENGSVRGRRGIEVLVGGSGGSDVDSIGTNTSQESRHETDHNNKQQYPAAALMPP 841
                                                 |||.|      ||.:..::..:.::..|
Human   499 -------------------------------------GTNLS------TDLSLNKEMGSLSIKDP 520

  Fly   842 PPPSLTNNHNHETIDEEEEVVIRPKARVPAVVKSANAQGLTKEEIELRNLRKKTRKRTRKFEIDG 906
                                                            .|.|||.||||||.:||
Human   521 ------------------------------------------------KLYKKTLKRTRKFVVDG 537

  Fly   907 VQMTTTTSRVIYGD---DENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQQAKEQQDRR 968
            |:::.|||::|..|   ||..|.     .|:||||||:||||:|.:.||:|..|.:...||..:|
Human   538 VEVSITTSKIISEDEKKDEEMRF-----LRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKR 597

  Fly   969 FEQERSSLEKTYEADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQEIR 1033
            ||||.::.:|.::.:::.|.||.||.|||.||......|..::|||.||:::...|:|.||...:
Human   598 FEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKK 662

  Fly  1034 LLKQEVDLFPKDKRKDEFKQRRSAMELDHEEK----ERAFLDSLKERHELLLRRLSEKHRDHLAT 1094
            .:|.||:..|:.:||:..||:   || :|.:|    :|.|:...||..||.::||:..:|..:..
Human   663 EVKNEVEKLPRQQRKESMKQK---ME-EHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICD 723

  Fly  1095 INRNFLQQKQNAMRTREALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQVKRML 1159
            ..|..|.:||..:|.|||.|||:||.||.|||||.|:.:|:..|:|||:::.:||||.:|::|..
Human   724 KERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYN 788

  Fly  1160 QRKEEDMVKKQTMEKRALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKFQEQEKKRYMQ 1224
            ||..|.:..:|..||..|||..|:|.|.|..|:::||.|:.......:|:::|:|.:||:||...
Human   789 QRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKS 853

  Fly  1225 EERRFEVKHQKQLEELRATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREWREQLV 1289
            |..:.:.||:.|:.::.|..||.:.||:||||||...|||||..||..:||.....|:|||::|.
Human   854 ERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLR 918

  Fly  1290 PRKQELNRQIKLAIDQHEKRFGLVTNREEFEDQEVKLPA 1328
            |||:.|...:.....:.|..|.|   .||.|......|:
Human   919 PRKKALEEDLNQKKREQEMFFKL---SEEAECPNPSTPS 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	168/278 (60%)
		S_TKc	37..295	CDD:214567	162/257 (63%)
		PKK	958..1095	CDD:289257	49/140 (35%)
		PKK	1126..1266	CDD:289257	57/139 (41%)
STK10	NP_005981.3	STKc_STK10	23..314	CDD:132975	173/290 (60%)
		S_TKc	36..294	CDD:214567	162/257 (63%)
		Activation segment	175..224		36/48 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..411		23/143 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..490		20/202 (10%)
		PKK	587..725	CDD:289257	49/141 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..690		9/25 (36%)
		PKK	755..895	CDD:289257	57/139 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	827..865		11/37 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..929		9/18 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..968		3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I999
eggNOG	1	0.900	-	-		E1_KOG0579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H38122
Inparanoid	1	1.050	718	1.000	Inparanoid score	I641
Isobase	1	0.950	-	0	Normalized mean entropy	S3222
OMA	1	1.010	-	-		QHG49250
OrthoDB	1	1.010	-	-		D365746at33208
OrthoFinder	1	1.000	-	-		FOG0002520
OrthoInspector	1	1.000	-	-		otm42032
orthoMCL	1	0.900	-	-		OOG6_105446
Panther	1	1.100	-	-	LDO	PTHR48012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3487
SonicParanoid	1	1.000	-	-		X1895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820