Protein Alignment Slik and PAK6

DIOPT Version :10

• Sequence 1: NP_726441.1
• Gene: Slik / 37893
• FlyBaseID: FBgn0035001
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_064553.1
• Gene: PAK6 / 56924
• HGNCID: 16061
• Length: 681
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 101/264 - (38%)
• Similarity: 161/264 - (60%)
• Gaps: 7/264 - (2%)

  Fly    32 DPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVE 96
            ||....:...::|:|:.|.|..|:.|...|..|.||..|..::.......|:.|:.:.:|.|:||
Human   402 DPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVE 466

  Fly    97 LYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKA 161
            :|:::.:.::||:|:|:..||||..|:.::.  |.|.|||.||:.:.:.|.:||...|||||:|:
Human   467 MYKSYLVGEELWVLMEFLQGGALTDIVSQVR--LNEEQIATVCEAVLQALAYLHAQGVIHRDIKS 529

  Fly   162 GNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGI 226
            .::|||::|.|||:|||..|:....:.|..:.:|||||||||::     ..:.|..:||||||||
Human   530 DSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-----SRSLYATEVDIWSLGI 589

  Fly   227 TLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQ 291
            .:||:...|||....||::.:.:::.|.||||:...:.|....|||::.||:|||.|.|...|:.
Human   590 MVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLD 654

  Fly   292 HAFI 295
            |.|:
Human   655 HPFL 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	101/264 (38%)
		PKK	958..1095	CDD:463600
		PKK	1126..1266	CDD:463600
PAK6	NP_064553.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		PBD	11..67	CDD:395634
		Linker	26..406		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..169
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..256
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	268..355
		STKc_PAK6	385..681	CDD:270821	101/264 (38%)