Protein Alignment Slik and slka

DIOPT Version :9

• Sequence 1: NP_726441.1
• Gene: Slik / 37893
• FlyBaseID: FBgn0035001
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_005156928.1
• Gene: slka / 568838
• ZFINID: ZDB-GENE-050411-66
• Length: 1232
• Species: Danio rerio
• Alignment Length: 1376
• Identity: 474/1376 - (34%)
• Similarity: 708/1376 - (51%)
• Gaps: 241/1376 - (17%)

  Fly     1 MSFITNLKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAA 65
            |||. |.:|:|.|  |..|||:.|.::..|.:|.:|||:||||||||||||||||:|:....|||
Zfish     1 MSFF-NFRKIFKL--GTEKKKKQYEHVNRDVNPEDFWEIVGELGDGAFGKVYKAQNKQTGILAAA 62

  Fly    66 KMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPL 130
            |:...:.||.|.|:|||||||:...|..||:|.:||..:.|||:|||:|.|||:|::|:|||:||
Zfish    63 KVIDTKTEEELEDYMVEIDILASCDHQYIVKLLDAFYYESKLWILIEFCAGGAVDAVMLELERPL 127

  Fly   131 TEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIG 195
            |||||..|||...|.|.:||.||:|||||||||:|.|.:|.:|||||||||||..|:|:.|:|||
Zfish   128 TEPQIRVVCKQSLEALVYLHENKIIHRDLKAGNILFTSDGNIKLADFGVSAKNTKTLQRRDSFIG 192

  Fly   196 TPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQ 260
            ||||||||:|:|||.:|.|||:|.||||||:|||||||:||||.||:||||||||.|||||.|..
Zfish   193 TPYWMAPEVVMCETSKDRPYDYKADIWSLGVTLIELAQIEPPNHEMNPMRVLLKIAKSEPPTLAS 257

  Fly   261 PSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDDETE 325
            |||||.||:|||:|:|.|:...|.:...|:||.|::..:|.||:::|:.|.||||.||..:.:.|
Zfish   258 PSRWSPEFSDFLRKALDKNVDNRWSALQLLQHPFVSSLVDNKPLRELIAEAKAEVFEEFEEGKEE 322

  Fly   326 EPRNSALQLDLDDDSASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAAATTTTKA 390
            |                                   .:|:.:|.|    |......|.:.|:..:
Zfish   323 E-----------------------------------EEEEPEPQS----AVQGHKRALSDTSVGS 348

  Fly   391 TTPDRPNHTKDDNAEAAAQQPPHTKVPAPAPPSSQQTPPPQVQQPPTPPAQPTAAVLQKKPEDVA 455
            :..:|.|                           |.||   ..:..|..|:|     ::||||.|
Zfish   349 SEDERQN---------------------------QNTP---TLESVTERAEP-----ERKPEDRA 378

  Fly   456 AVAETSEKTESDKKHFVKKGKAPPPPSPLGLANAKPAASDSQTSPKKLATPEPTSPVTTAIEVAI 520
            ....::...::::.:.::.||       :..||....:::...|..:|.:.:..||:..:.|..:
Zfish   379 CDKTSAMVVDANESNHLEDGK-------IVEANVSDTSAEELRSGDELISKQEESPMPVSTEGGV 436

  Fly   521 GQEAMEPKPQPPSPTASSIVSVQSVASSSSSG-------SVSNAVLSSSTSLITINSDPPTPHHH 578
                   ..||.:|||:.....:.|..|..:|       .|...:.........||.....
Zfish   437 -------TDQPNAPTANDTNLQEIVTVSEETGEEEKKEVKVEEKLEKKEEESEEINMKAKA---- 490

  Fly   579 QPLPPQPQHLILP-------NSLESVSQ------ITVVTSTHPPVIIDNSV--MPPQNEVIIVSN 628
            |.:..:.:...||       |..:.|::      |.|...|...:..:..|  ..|:.:..:.|.
Zfish   491 QSITDEEKEHALPSDEAEPKNKSDGVTEEAITELIEVTEKTEDKLENEEEVHGKEPEEDKTVTSA 555

  Fly   629 DMNKSTHLHESSTDDDFPSLDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQTSSTVHARK 693
            |: .:..|.|.:         ::|.|.:|...|:                  .||:.|..|...:
Zfish   556 DV-PTEKLKEQT---------ETLPDVSTEEVKK------------------EQPEASPDVSTEE 592

  Fly   694 LDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHVSVVTVGDEGVKVKDSSNELVKRQ- 757
            :.|..               .|..|:.|.:......:|              :.|:|:|.||:|
Zfish   593 VKEQP---------------ETLPGASSEEVKKEQPET--------------LPDASSEEVKKQP 628

  Fly   758 -PNGVGIV-------PEDVNIIVNRFKQEKRSPD--SSLSENGSVRGRRGIE------------V 800
             |:..|..       ||....:....|:::..|:  :...|...:...||::            |
Zfish   629 EPSPKGSTEEVKEEQPETSPEVSKEVKEDQLVPEDQNKTEEKAEITEPRGVDVVEDISLSKVPVV 693

  Fly   801 LVGGSGGSDVDSIGTNTSQESRHETDHNNKQQYPAAALMPPPPPSLTNNHNHETIDEEEEVVIRP 865
            ::.|....:|.:    |.:.:....|....|:.||   ||        ..:|.|:|     |.:|
Zfish   694 VINGVKEEEVSA----TEEPAEAPEDRPEIQEAPA---MP--------ESDHNTVD-----VAKP 738

  Fly   866 KARVPAVVKSANAQGLTKEEIELRNL---------------------RKKTRKRTRKFEIDGVQM 909
            .|.......|.::.......|:: ||                     :|||.|:||||.:|||::
Zfish   739 DAEKEKDSDSGSSSAADTNSIDI-NLSISSFLSKSKEGSVSIQDIKRQKKTLKKTRKFLVDGVEV 802

  Fly   910 TTTTSRVIYGDDENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQQAKEQQDRRFEQERS 974
            :.|||:::..:|....  :....|:||||||:||||:|::.|.:|..|.||.|||..||||||.|
Zfish   803 SVTTSKIVTDNDTKSE--ELRFLRRQELRELRLLQKEEQRAQQQLSNKLQQQKEQLFRRFEQEMS 865

  Fly   975 SLEKTYEADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQEIRLLKQEV 1039
            ..::.|:.:::.|.:|.||.:|:.||...|.||..:|||::||::||..|:..||...:.:||||
Zfish   866 GKKRQYDQEVENLEKQQKQTIERLEQDHTNRLRDEAKRIKAEQDKELSKFQNMLKNRKKEVKQEV 930

  Fly  1040 DLFPKDKRKDEFKQRRSAMELDHEEKERAFLDSLKERHELLLRRLSEKHRDHLATINRNFLQQKQ 1104
            .|.||..||:..|:.:..:......:|:.||...::..:..|:::.::|:..:|||.|:.|..||
Zfish   931 GLSPKHMRKELMKRLKEDLAAIQHGEEQEFLQRQQQELDGALKKIIQQHKLEIATIERDCLNHKQ 995

  Fly  1105 NAMRTREALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQVKRMLQRKEEDMVKK 1169
            ..||.|||.:|||||:.|.|:|||.|:.:|:..||||||::.||:||::|::...||..|:|..:
Zfish   996 QLMRAREAAMWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHDKEMEQMQGYNQRLIEEMKNR 1060

  Fly  1170 QTMEKRALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKFQEQEKKRYMQEERRFEVKHQ 1234
            |..|:..|||..|:|.|.|..||::||||:....||.:|:::|:|..||.||...|......||:
Zfish  1061 QAQERARLPKIQRSEAKTRMAMFKKSLRITGTGTPEQDREKIKQFAVQEDKRQKNERLHQHQKHE 1125

  Fly  1235 KQLEELRATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREWREQLVPRKQELNRQI 1299
            .|:.:|:...:|.|:||:|:||||...|:|||..||.|:||....||:||||:|.|||:.|..:.
Zfish  1126 NQMRDLQLQCDSNIRELQQMQNEKCHLLIEHETQKLKELDEEHSQELKEWREKLRPRKKALEEEF 1190

  Fly  1300 KLAIDQHEKRF 1310
            ...:.:.|..|
Zfish  1191 TRKLQEQEVFF 1201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	174/278 (63%)
		S_TKc	37..295	CDD:214567	167/257 (65%)
		PKK	958..1095	CDD:289257	49/136 (36%)
		PKK	1126..1266	CDD:289257	60/139 (43%)
slka	XP_005156928.1	STKc_SLK	28..310	CDD:270811	175/281 (62%)
		S_TKc	34..292	CDD:214567	167/257 (65%)
		PKK	849..987	CDD:289257	50/137 (36%)
		PKK	1017..1157	CDD:289257	60/139 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I953
eggNOG	1	0.900	-	-		E1_KOG0579
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49250
OrthoDB	1	1.010	-	-		D365746at33208
OrthoFinder	1	1.000	-	-		FOG0002520
OrthoInspector	1	1.000	-	-		otm25957
orthoMCL	1	0.900	-	-		OOG6_105446
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.790