DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slik and slkb

DIOPT Version :9

Sequence 1:	NP_726441.1	Gene:	Slik / 37893	FlyBaseID:	FBgn0035001	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001315314.1	Gene:	slkb / 562769	ZFINID:	ZDB-GENE-030131-1684	Length:	969	Species:	Danio rerio

Alignment Length:	1317	Identity:	430/1317 - (32%)
Similarity:	633/1317 - (48%)	Gaps:	386/1317 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFITNLKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAA 65
            |||. |.:|:|.|  |..|||:.|:::..||:|.|.||:||||||||||||:|||:|:...||||
Zfish     1 MSFF-NFRKIFKL--GIEKKKKQYDHVHRDTNPEEIWEIVGELGDGAFGKVFKAQNKQTGIFAAA 62

  Fly    66 KMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPL 130
            |:...:.|:.|.|:|||||||:...|.|||:|.:||..:.|||:|||:|.|||:|::|:|||:||
Zfish    63 KVIDTKTEDELEDYMVEIDILASCDHHNIVKLLDAFYFESKLWILIEFCAGGAVDAVMLELERPL 127

  Fly   131 TEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIG 195
            |||||..|||...:.|.:||.||||||||||||:|||::|.||||||||||||..|:|:.|:|||
Zfish   128 TEPQIRVVCKQTLDALLYLHDNKVIHRDLKAGNILLTLDGDVKLADFGVSAKNTKTVQRRDSFIG 192

  Fly   196 TPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQ 260
            ||||||||:|:|||.:|.|||:|.||||||||||||||:||||.||:||||||||.|:|||.|.|
Zfish   193 TPYWMAPEVVMCETSKDRPYDYKADIWSLGITLIELAQIEPPNHEMNPMRVLLKIAKAEPPTLLQ 257

  Fly   261 PSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDDE-T 324
            ||:||.||.||||.:|.|:...|.:|..|:||.|::...|::|:::|:.|.||||.||:.::| .
Zfish   258 PSKWSPEFRDFLKHALEKNVDNRWSTAQLLQHPFVSTVTDSRPLRELIAEAKAEVTEEMEEEEDD 322

  Fly   325 EEPRNSALQLDLDDDSASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAAATTTTK 389
            ||...:.|........||:.|.:.:|||.:|:::
Zfish   323 EEHEGNLLGHKRAPSDASVGSSEDEKLPQSPSTL------------------------------- 356

  Fly   390 ATTPDRPNHTKDDNAEAAAQQPPHTKVPAPAPPSSQQTPPPQVQQPPTPPAQPTAAVLQKKPEDV 454
                                                ::.|.::::...|          |..:|:
Zfish   357 ------------------------------------ESVPERIEEVSAP----------KLADDI 375

  Fly   455 --AAVAETSEKTESDKKHFVKKGKAPPPPSPLGLANAKPAASDSQTSPKKLATPEPTSPVTTAIE 517
              |.:.:..:..::::.|.:.|                 |||:|  :.::|.|..
Zfish   376 VTAEIKKEEDPLKTEENHILDK-----------------AASES--NKQELKTEG---------- 411

  Fly   518 VAIGQEAMEPKPQPPSPTASSIVSVQSVASSSSSGSVSNAVLSSSTSLITINSDPPTPHHHQPLP 582
                    ||...|....|..|:                                      ||..
Zfish   412 --------EPDVVPSETPAEGII--------------------------------------QPAK 430

  Fly   583 PQPQHLILPNSLESVSQITVVTSTHPPVIIDNSVMPPQNEVIIVSNDMNKSTHLHESSTDDDFPS 647
            |..:.|                               :.|.::.:.::.:.
Zfish   431 PDGEKL-------------------------------REEEVLGNGELVQK-------------- 450

  Fly   648 LDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQTSSTVHARKLDESEVLIVSPSYA---DD 709
              :...|..:|..|:.::|   .|.:..|  .||.|........:..||.:...|.|.|.   |.
Zfish   451 --EPASDVCSPTDKEKAVI---EESSKAV--APSSPVPEKEKKEKLEDEQKQSPVKPHYVKKEDS 508

  Fly   710 DSAYNTASGSHSHDHSDHLMDTSHVSVVTVGDEGVKVKDSSNELVKRQPNGVGIVPEDVNIIVNR 774
            ||..::.:.:.|:..|                                        .|:|:.::.
Zfish   509 DSGISSTTDTSSNSSS----------------------------------------IDLNLSISS 533

  Fly   775 FKQEKRSPDSSLSENGSVRGRRGIEVLVGGSGGSDVDSIGTNTSQESRHETDHNNKQQYPAAALM 839
            |..:.:                               .:|||:.|:        ||:|
Zfish   534 FISKSK-------------------------------EMGTNSQQD--------NKRQ------- 552

  Fly   840 PPPPPSLTNNHNHETIDEEEEVVIRPKARVPAVVKSANAQGLTKEEIELRNLRKKTRKRTRKFEI 904
                                                                 |||.|:||||.:
Zfish   553 -----------------------------------------------------KKTLKKTRKFMV 564

  Fly   905 DGVQMTTTTSRVIYGDDENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQQAKEQQDRRF 969
            |||:::.|||::|..:|....  :....|:||||||:||||:|::.|.:|..|.||.::|..|||
Zfish   565 DGVEVSVTTSKIITDNDTKNE--EMRFLRRQELRELRLLQKEEQRAQQQLSNKLQQQRDQICRRF 627

  Fly   970 EQERSSLEKTYEADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQEIRL 1034
            |.|.:|.::.|:.:::.:.||.||.:|:.||.....||..:|||::||::||..|:...|.
Zfish   628 EHETTSKKRQYDTEVENMERQQKQTIERLEQEHTERLRDEAKRIKAEQDKELSKFQNTHKN---- 688

  Fly  1035 LKQEVDLFPKDKRKDEFKQRRSAMELDHEEKERAFLDSLKERHELLLRRLSEKHRDHLATINRNF 1099
                     :.|.:.||.|           |::..|||       .|:::.::|:..|||..|:.
Zfish   689 ---------RKKEEQEFVQ-----------KQQQDLDS-------ALKKIIQQHKLELATTERDC 726

  Fly  1100 LQQKQNAMRTREALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQVKRMLQRKEE 1164
            |..||..:|.|||.:|||||:.|.|:|||.|:.:|:..||||||::.|||||::|:.|..||..|
Zfish   727 LNHKQQLLRAREAAMWELEERHLQEKHQLYKQQLKDQYFMQRHQLLKRHEKEMEQMHRYNQRLME 791

  Fly  1165 DMVKKQTMEKRALPKRIRAERKARDLMFRESLRI-STNLDPEIERDRLKKFQEQEKKRYMQEERR 1228
            ||..:|..||..|||..|::.|.|..||::|||| :|.:..|:||:|:|:|..||:||...|...
Zfish   792 DMKNRQMQEKTRLPKIQRSDAKTRMAMFKKSLRITTTGVTAELERERVKQFAAQEEKRQKNERLH 856

  Fly  1229 FEVKHQKQLEELRATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREWREQLVPRKQ 1293
            .:.||:.|:.:|:...::..:||:||||||...|:|||..||.|:||....||::|||:|.|||:
Zfish   857 QQQKHENQMRDLQTQCDANSRELQQLQNEKCHLLIEHETQKLKELDEEHGAELKDWREKLRPRKK 921

  Fly  1294 ELNRQIKLAIDQHEKRF 1310
            .|..:....:.:.|..|
Zfish   922 ALEEEFARKLQEQEVFF 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	177/278 (64%)
		S_TKc	37..295	CDD:214567	170/257 (66%)
		PKK	958..1095	CDD:289257	40/136 (29%)
		PKK	1126..1266	CDD:289257	64/140 (46%)
slkb	NP_001315314.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I953
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	743	1.000	Inparanoid score	I570
OMA	1	1.010	-	-		QHG49250
OrthoDB	1	1.010	-	-		D365746at33208
OrthoFinder	1	1.000	-	-		FOG0002520
OrthoInspector	1	1.000	-	-		otm25957
orthoMCL	1	0.900	-	-		OOG6_105446
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3487
SonicParanoid	1	1.000	-	-		X1895
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010