DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slik and fray

DIOPT Version :9

Sequence 1:	NP_726441.1	Gene:	Slik / 37893	FlyBaseID:	FBgn0035001	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001303449.2	Gene:	fray / 44233	FlyBaseID:	FBgn0023083	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	146/559 - (26%)
Similarity:	234/559 - (41%)	Gaps:	109/559 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSD 78
            |.....:|..:.|.|.|      :|:...:|.||...|:.|....:....|.|...||......|
  Fly   176 GAAAPPEKYTWPNSKDD------YELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMD 234

  Fly    79 HMV-EIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKP-------LTEPQI 135
            .:: ||..:|...|.|:|..:.:|.:.::||:::...:||:|..|:....:.       ..|..|
  Fly   235 ELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQGVFDEATI 299

  Fly   136 AYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSA-----KNKHTMQKHDTFIG 195
            |.|.|.:.:||.:.|.|..||||:||||:|:..:|.:::|||||||     ::....:...||:|
  Fly   300 ATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKVRHTFVG 364

  Fly   196 TPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKL-- 258
            ||.|||||::    .:|:.||.|.||||.|||.||:|....|..:..||:||:...:::||.|
  Fly   365 TPCWMAPEVM----EQDHGYDFKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDT 425

  Fly   259 -----EQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEE 318
                 :|...:.|.|...:.:.|.|:|..|||...|::|||..:..|.|.:...||:
  Fly   426 GADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFFKKAKDRKYLTQTLLQ-------- 482

  Fly   319 VVDDETEEPRNSALQLDLDDDSASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAA 383
                                           ..|...|.:.:.||.  ||.:|..:....|....
  Fly   483 -------------------------------SGPSMETRVHKAAKR--QPGASGRLHRTVTGEWV 514

  Fly   384 --------ATTTTKATTPDRPNHTKDDNAEAAAQQPPHTKVPAPAPPSSQQTPPPQ----VQQPP 436
                    ..:.|.:.|.||.:.:.|.::|   .:|.:....|.:..|.::.|.|:    |....
  Fly   515 WSSEEEDNGGSATGSGTGDRKHPSSDSDSE---DRPMNRLERADSSDSDREEPSPEITHSVSSAT 576

  Fly   437 TPPAQPTAAVLQKKPEDVAAVAETSEKTESDKKHFVKKGKAPPPPSPLGLANAKPAASD------ 495
            ..|..|.||......|..|.:|:....:|:       .|:|||....|.:.|.:....|
  Fly   577 VTPGAPAAAGAGAAQELTAGIAQLPLPSEA-------AGEAPPVNLVLRMRNLRRELHDIRFEFV 634

  Fly   496 -SQTSPKKLAT---------PEPTSPVTTAIEVAIGQEA 524
             .:.:.:.:||         ...|.|:.|.::..|...|
  Fly   635 VGKDTAEGIATELVDAGLVDALDTQPMATHLDQLIAASA 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	98/298 (33%)
		S_TKc	37..295	CDD:214567	94/277 (34%)
		PKK	958..1095	CDD:289257
		PKK	1126..1266	CDD:289257
fray	NP_001303449.2	STKc_OSR1_SPAK	191..467	CDD:270787	95/285 (33%)
fray	NP_001303449.2	OSR1_C	613..670	CDD:403428	8/56 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940