DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slik and GckIII

DIOPT Version :9

Sequence 1:	NP_726441.1	Gene:	Slik / 37893	FlyBaseID:	FBgn0035001	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_650596.1	Gene:	GckIII / 42064	FlyBaseID:	FBgn0266465	Length:	642	Species:	Drosophila melanogaster

Alignment Length:	803	Identity:	211/803 - (26%)
Similarity:	327/803 - (40%)	Gaps:	236/803 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLED-EENLSDHMVEIDILSEIKHPNIV 95
            ||...:.....:|.|:||:|:|......::..|.|:..||: |:.:.|...||.:||:...|.:.
  Fly     8 DPELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQCDSPYVT 72

  Fly    96 ELYEAFSIDDKLWMLIEYCDGG-ALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDL 159
            :.|.:|....|||:::||..|| |||.:..   ....|..|..:.:.:.:||.:||..:.:|||:
  Fly    73 KYYGSFLKGTKLWIIMEYLGGGSALDLMKA---GSFEEMHIGIILREVLKGLDYLHSERKLHRDI 134

  Fly   160 KAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSL 224
            ||.||||:.:|.||||||||:.:..:|..|.:||:|||:|||||::     :.:.||.|.|||||
  Fly   135 KAANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVI-----KQSQYDAKADIWSL 194

  Fly   225 GITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVL 289
            |||.||||:.||||||:.|||||..|.|:.||:|  ...::|.|.||::..|.|||:.|||...|
  Fly   195 GITAIELAKGEPPNSELHPMRVLFLIPKNNPPQL--TGSYTKSFKDFVEACLNKDPENRPTAKEL 257

  Fly   290 MQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDDETEEPRNSALQLDLDDDSASLQSQDIDKLPGT 354
            :::.||.:......:.||:..:|...|.:..:.|||. .||      |.||
  Fly   258 LKYPFIKKAKKNAYLIDLIDRFKKWKVSKGDESETES-ENS------DSDS-------------- 301

  Fly   355 PTSILRDAKEQSQPSSSLPIAAAATAAAAATTTTKATTPDRPNHTKDDNAEAAAQQPPHTKVPAP 419
                  |||:..
  Fly   302 ------DAKQGG----------------------------------------------------- 307

  Fly   420 APPSSQQTPPPQVQQPPTPPAQPTAAV----LQKKPEDVAAVAETSEKTESDKKHFVKKGKAPPP 480
               |||..|.....:.....:.|.|.|    ||:....:..:.:|:..
  Fly   308 ---SSQDEPWIMTVKGLHINSAPRAGVNSFQLQEHELTMQKLMQTTHS----------------- 352

  Fly   481 PSPLGLANAKPAASDSQTSPKKLATPEPTSPVTTAIEVAIGQEAMEPKPQPPSPTASSIVSVQSV 545
            |:..|...|.|||:                                        ..||  ||.:|
  Fly   353 PAGGGGVQASPAAN----------------------------------------ALSS--SVSAV 375

  Fly   546 ASSSSSGSV--SNAVLSSSTSLITINSDPPTPHHHQPLPPQPQHL-------ILPNSLESVSQ-- 599
            |:|:||.||  :|..:||:::                ||||..|:       |..|::.::|.
  Fly   376 AASASSVSVITANEGVSSASA----------------LPPQNSHVHNHNHNNINNNNIRNLSNKH 424

  Fly   600 --ITVVTSTHPPVIIDNSVMPPQNEVIIVSNDMNKSTHLHESSTDDDFPSLDDSLGDATTPPHKQ 662
              .|::.:..||    :||....:...:.....:....|.:|.:......::|.......|  .|
  Fly   425 ATTTMLNAAPPP----SSVTSSSSASELQQKRSSSKPELRQSRSAAPLDQVEDRRASLGLP--LQ 483

  Fly   663 SSMILAVNEPAGVVPAPPSQPQTSSTVHARKLDESEVLIVSPSYADDDSAY--NTASGSHSHDHS 725
            ||           ||.    |.|:.....|:..:.|      |:..:::|.  :.:|.|::|.|.
  Fly   484 SS-----------VPT----PSTAEQQQQRRSSQRE------SFHANNAALVASCSSSSNNHSHE 527

  Fly   726 DHLMDTSHVSVVTVGDEGVKVKDSSNELVKRQPNGVGIVPEDVNIIVNRFKQEKRSPDSSLSENG 790
            :|:. |:|.|.|.....|.::..:::..:.   |.:..|..|:        |.|.|...|....|
  Fly   528 EHVA-TNHASHVKHSGAGQRLVQTNSACLN---NFLFPVLSDI--------QRKYSGGGSAGSGG 580

  Fly   791 SVRGRRGIEVLVGGSGGSDVDSI 813
            |  |.|.|.|      |||:..:
  Fly   581 S--GGRNIGV------GSDIGDL 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	114/279 (41%)
		S_TKc	37..295	CDD:214567	108/259 (42%)
		PKK	958..1095	CDD:289257
		PKK	1126..1266	CDD:289257
GckIII	NP_650596.1	STKc_MST3_like	12..283	CDD:270786	113/280 (40%)
GckIII	NP_650596.1	S_TKc	13..263	CDD:214567	108/259 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438546
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940