DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slik and Mkk4

DIOPT Version :9

Sequence 1:	NP_726441.1	Gene:	Slik / 37893	FlyBaseID:	FBgn0035001	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster

Alignment Length:	293	Identity:	90/293 - (30%)
Similarity:	146/293 - (49%)	Gaps:	18/293 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GELGDGAFGKVYKAQHKE-QKRFAAAKMCQLEDEENLSDHMVEIDILSEIKH-PNIVELYEAFSI 103
            ||:|.||||.|.|...|: .|..|..::....||:.....:::::::.:... ..||:.|.|...
  Fly   126 GEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFK 190

  Fly   104 DDKLWMLIEYCDGGALDS----IMVELEKPLTEPQIAYVCKHMTEGLTFLHRN-KVIHRDLKAGN 163
            :...|:.:|..| .:||.    |..:.::.:.|..:|.:.......|.:|... |:||||:|..|
  Fly   191 EGDCWICMELMD-TSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSN 254

  Fly   164 VLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITL 228
            :||...|.:||.|||:|.:...::.|.......|| ||||.:  :..|...||.:.|:|||||||
  Fly   255 ILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPY-MAPERI--DPERAKGYDVRSDVWSLGITL 316

  Fly   229 IELAQMEPPNSEM-SPMRVLLKIQKSEPPKL---EQPSRWSKEFNDFLKKSLVKDPQVRPTTDVL 289
            :|:|....|..:. |....|.::.:.|||:|   .....:||||.||:...|:|....||....|
  Fly   317 MEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRL 381

  Fly   290 MQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDD 322
            ::..||.|...:.  .|:.: |.|:::|.:..|
  Fly   382 LEMPFIRRGETSH--TDVAV-YVADILESMEKD 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	86/279 (31%)
		S_TKc	37..295	CDD:214567	82/264 (31%)
		PKK	958..1095	CDD:289257
		PKK	1126..1266	CDD:289257
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	88/285 (31%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	82/264 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910