DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slik and hpo

DIOPT Version :9

Sequence 1:	NP_726441.1	Gene:	Slik / 37893	FlyBaseID:	FBgn0035001	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	897	Identity:	210/897 - (23%)
Similarity:	327/897 - (36%)	Gaps:	302/897 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVEL 97
            |.:.::::.:||:|::|.||||.|||.....|.|:..:|.:  |.:.:.||.|:.:...|.:|..
  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESD--LHEIIKEISIMQQCDSPYVVRY 100

  Fly    98 YEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAG 162
            |.::.....||:.:|||..|::..||...:|.|||.:||.:.....:||.:||..:.||||:||.
  Fly   101 YGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAA 165

  Fly   163 NVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGIT 227
            |:||..||..|||||||:.:...||.|.:|.||||:|||||::     .:..||...||||||||
  Fly   166 NILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----EEIGYDCVADIWSLGIT 225

  Fly   228 LIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQH 292
            .:|:|:.:||..|:.|||.:..|.:..||...:|.|||.||.||:.|.|||:|..|.|...|::|
  Fly   226 ALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEH 290

  Fly   293 AFINRNLDAKPIKDLLLEYKAEVVEEVVDDETEEPRNSALQLDLDDDSASLQSQDIDKLPGTPTS 357
            .|| ||...:.|...:||....:
  Fly   291 EFI-RNAKHRSILKPMLEETCAI------------------------------------------ 312

  Fly   358 ILRDAKEQSQPSSSL-PIAAAATAAAAATTTTKATTPDRPNHTKDDNAEAAAQQPPHTKVPAPAP 421
                 :||.:.:.|. .:.||:.|.:.||         :.|..:....:.|..:.|.|.||
  Fly   313 -----REQQRANRSFGGVLAASQAKSLAT---------QENGMQQHITDNAFMEDPGTLVP---- 359

  Fly   422 PSSQQTPPPQVQQPPTPPAQPTAAVLQKKPEDVAAVAETSEKTESDKKHFVKKGKAPPPPSPLGL 486
                               :......|....|...:|...:.        |.:|..    .|.||
  Fly   360 -------------------EKFGEYQQSSASDATMIAHAEQG--------VDEGTL----GPGGL 393

  Fly   487 AN----AKPAASDSQTSPKKLATPEPTSPVTTAIEVAIGQEAMEPKPQPPSPTASSIVSVQSVAS 547
            .|    |.|||:.|..||..:                            |:..:.::|.::|
  Fly   394 RNLSKAAAPAAASSAASPLDM----------------------------PAVDSGTMVELES--- 427

  Fly   548 SSSSGSVSNAVLSSSTSLITINSDPPTPHHHQPLPPQPQHLILPNSLESVSQITVVTSTHPPVII 612
                        :..|.:|..:||..|...:.. ..:|::...|..||
  Fly   428 ------------NLGTMVINSDSDDSTTAKNND-DQKPRNRYRPQFLE----------------- 462

  Fly   613 DNSVMPPQNEVIIVSNDMNKSTHLHESSTDDDFPSLDDSLGDATTPPHKQSSMILAVNEPAGVVP 677
                                  |.       |..:..|..||        ...|.....||
  Fly   463 ----------------------HF-------DRKNAGDGRGD--------EKPIATEYSPA---- 486

  Fly   678 APPSQPQTSSTVHARKLDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHVSVVTVGDE 742
            |...|.|.......::.||..:                |||::..::.:|.|:.....:..:...
  Fly   487 AAEQQQQQQQQQQQQQQDEQHL----------------ASGANDLNNWEHNMEMQFQQISAINQY 535

  Fly   743 GVKVKDSSNELVKRQPNGVGIVPEDVNIIVNRFKQEKRSPDSSLSENGSVRGRRGIEVLVGGSGG 807
            |::......:::...|    ::.|.:..:.|:       |:..|| |.:..|::||
  Fly   536 GLQQHQQQQQVLMAYP----LMNEQLIALNNQ-------PNLLLS-NAAPMGQQGI--------- 579

  Fly   808 SDVDSIGTNTSQESRHETDHNNKQQYPAAALMPPPPPSLTNNHNHE------------------- 853
                                      |||| ...|||:..|.|.|.
  Fly   580 --------------------------PAAA-PAQPPPAYQNQHMHTQSHAYVEGEFEFLKFLTFD 617

  Fly   854 -------TIDEEEEVVI-----RPKARVPAVVKSANAQGLTKEEIELRNLRK 893
                   .||.|.|:.|     :..|:...:|.:.||:...::.|. .||.|
  Fly   618 DLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKRKRQQNIN-NNLIK 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	114/276 (41%)
		S_TKc	37..295	CDD:214567	108/257 (42%)
		PKK	958..1095	CDD:289257
		PKK	1126..1266	CDD:289257
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	109/261 (42%)
		S_TKc	42..293	CDD:214567	108/257 (42%)
		Mst1_SARAH	608..655	CDD:288481	8/46 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840