Protein Alignment Slik and Stk10

DIOPT Version :10

• Sequence 1: NP_726441.1
• Gene: Slik / 37893
• FlyBaseID: FBgn0035001
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_062079.2
• Gene: Stk10 / 29398
• RGDID: 3779
• Length: 980
• Species: Rattus norvegicus
• Alignment Length: 1355
• Identity: 426/1355 - (31%)
• Similarity: 615/1355 - (45%)
• Gaps: 394/1355 - (29%)

  Fly     1 MSFITNLKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAA 65
            |:| .|.:::..|...|.:|.|.|.:::.|.||.:.||::||||||||||||||::||....|||
  Rat     1 MAF-ANFRRILRLSTFEKRKSREYEHVRRDLDPNDVWEILGELGDGAFGKVYKAKNKETGALAAA 64

  Fly    66 KMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPL 130
            |:.:.:.||.|.|::|||:||:...||.||:|..|:..|.|||::||:|.|||:|:||:||::.|
  Rat    65 KVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYYDGKLWIMIEFCPGGAVDAIMLELDRGL 129

  Fly   131 TEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIG 195
            |||||..||:.|.|.|.|||..::|||||||||||:|:||.::||||||||||..|:||.|:|||
  Rat   130 TEPQIQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIG 194

  Fly   196 TPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQ 260
            ||||||||:|||||.:|.|||:|.|||||||||||:||:|||:.|::||||||||.||:||.|..
  Rat   195 TPYWMAPEVVLCETMKDAPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLT 259

  Fly   261 PSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVD---D 322
            ||:||.||.||||.:|.|:|:.||:...|:||.|::.....|.:::|:.|.||||:||:.|   |
  Rat   260 PSKWSTEFRDFLKIALDKNPETRPSAAQLLQHPFVSTVTSNKALRELVAEAKAEVMEEIEDGKED 324

  Fly   323 ETEEPRNSALQLDLDDDSASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAAATTT 387
            ..|:.|....:.|.|:..|
  Rat   325 GREDGREDGEEEDGDEKDA---------------------------------------------- 343

  Fly   388 TKATTPDRPNHTKDDNAEAAAQQPPHTKVPAPAPPSSQQTPPPQVQQPPTPPA-QPTAAVLQKKP 451
             .:..|...|||:|.:|...   .|..........||...||.|.|:|...|. ||:.   ...|
  Rat   344 -VSAVPPPVNHTQDSSANGT---QPSLNSDKLLQDSSTPLPPSQPQEPVNGPCNQPSG---DGSP 401

  Fly   452 EDVAAVAETSEKTESDKKHFVKKGKAPPPPSPLGLANAKPAASDS--QTSPKKLATPEPTSPVTT 514
            ::.:...|.|:.....|             .|:.|..::|.:.|:  |.:.:|..|.:..:|.:.
  Rat   402 QNTSPADEVSKNDNGLK-------------VPVPLRKSRPLSVDARIQVTEEKQITDQAENPSSA 453

  Fly   515 AIEVAIGQEAMEPKPQPPSPTASSI--VSVQSVASSSSSGSVSNAVLSSSTSLITINSDPPTPHH 577
            |        :..||.....|.:|::  :.|:::|:..
  Rat   454 A--------SKPPKVNQSRPNSSALETLGVETLANGG---------------------------- 482

  Fly   578 HQPLPPQPQHLILPNSLESVSQITVVTSTHPPVIIDNSVMPPQNEVIIVSNDMNKSTHLHESSTD 642
                      |.||.|:
  Rat   483 ----------LELPGSV------------------------------------------------ 489

  Fly   643 DDFPSLDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQTSSTVHARKLDESEVLIVSPSYA 707
                          ||
  Rat   490 --------------TP------------------------------------------------- 491

  Fly   708 DDDSAYNTASGSHSHDHSDHLMDTSHVSVVTVGDEGVKVKDSSNELVKRQPNGVGIVPEDVNIIV 772
                           :||....|.|::|.....|.|..:
  Rat   492 ---------------NHSKRASDCSNLSTSESMDYGTSL-------------------------- 515

  Fly   773 NRFKQEKRSPDSSLS-ENGSVRGRRGIEVLVGGSGGSDVDSIGTNTSQESRHETDHNNKQQYPAA 836
                    |.|.||: |.||:
  Rat   516 --------SADLSLNKETGSL-------------------------------------------- 528

  Fly   837 ALMPPPPPSLTNNHNHETIDEEEEVVIRPKARVPAVVKSANAQGLTKEEIELRNLRKKTRKRTRK 901
                    ||..:                                        .|..||.||||:
  Rat   529 --------SLKGS----------------------------------------KLHNKTLKRTRR 545

  Fly   902 FEIDGVQMTTTTSRVIYGD---DENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQQAKE 963
            |.:|||:::.|||::|..|   ||..|.     .|:||||||:||||:|.:.||:|..|.:...|
  Rat   546 FVVDGVEVSITTSKIISEDEKKDEEMRF-----LRRQELRELRLLQKEEHRNQTQLSTKHELQLE 605

  Fly   964 QQDRRFEQERSSLEKTYEADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENL 1028
            |..||||||.::.:|.|:.:::.|.||.||.|||.||......|..:||||.||:::...|:|.|
  Rat   606 QMHRRFEQEINAKKKFYDVELENLERQQKQQVEKMEQDHSVRRREEAKRIRLEQDRDYARFQEQL 670

  Fly  1029 KQEIRLLKQEVDLFPKDKRKDEFKQRRSAMELDHEEKERAFLDSLKERHELLLRRLSEKHRDHLA 1093
            ||..:.:|..|:...::.|.....|.::........::|.|:...||..||.:::|:.::|..:.
  Rat   671 KQMKKEVKLTVERLARNSRNSSSFQEQTEHPQAARRRDRDFVAKQKEDLELAMKKLTAENRREIC 735

  Fly  1094 TINRNFLQQKQNAMRTREALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQVKRM 1158
            ...|:.|.:||..:|.|||.|||:||.||.|||||.|:.:|:..|:|||.::.:||||.:|::|.
  Rat   736 DKERDCLNKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHDLLRKHEKEREQMQRY 800

  Fly  1159 LQRKEEDMVKKQTMEKRALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKFQEQEKKRYM 1223
            .||..|.:..:|..||..|||..|::.|.|..|:::||.|:.......:|:::|:|.:||:||..
  Rat   801 NQRMMEQLKVRQQQEKARLPKIQRSDGKTRMAMYKKSLHINGAGSASEQREKVKQFSQQEEKRQK 865

  Fly  1224 QEERRFEVKHQKQLEELRATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREWREQL 1288
            .|..:.:.||:.|:.::.|..||.:.||:||||||...|||||..||..:||.....|:|||::|
  Rat   866 AERLQQQQKHENQMRDMVAQCESNMNELQQLQNEKCHLLVEHETQKLKALDESHNQSLKEWRDKL 930

  Fly  1289 VPRKQELNRQIKLAIDQHEKRFGLVTNREEFEDQEVKLPAHLRNIYNERSSRILP 1343
            .|||:.|...:.....:.|..|.|   .||         |..|.....|:|:..|
  Rat   931 RPRKKALEEDLNQKKREQEMFFRL---SEE---------AETRPTTPNRASKFFP 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	168/278 (60%)
		PKK	958..1095	CDD:463600	44/136 (32%)
		PKK	1126..1266	CDD:463600	56/139 (40%)
Stk10	NP_062079.2	STKc_STK10	23..314	CDD:132975	173/290 (60%)
		PKK	600..738	CDD:463600	44/137 (32%)
		PKK	768..908	CDD:463600	56/139 (40%)